Effect of caloric restriction with and without exercise training on oxidative stress and endothelial function in obese subjects with type 2 diabetes

Diabetes, Obesity & Metabolism
T P WycherleyP M Clifton

Abstract

Effects of dietary weight loss on endothelial function, particularly when combined with exercise training, is largely unknown in type 2 diabetes. We sought to determine whether aerobic exercise training provided any additional improvements in endothelial function, oxidative stress or other established markers of cardiovascular risk when combined with an energy-restricted diet in patients with type 2 diabetes. In a parallel study design, 29 sedentary, overweight and obese patients with type 2 diabetes (age 52.4 +/- 1.4 years and BMI 34.2 +/- 0.9 kg/m(2)) were randomized to a 12-week moderate energy-restricted diet (~5000 kJ/day and approximately 30% energy deficit) with or without aerobic exercise training [diet only (D), n = 16 and diet plus exercise (DE), n = 13]. Body weight, cardiovascular risk markers, malondialdehyde (MDA, oxidative stress marker), 24-h urinary nitrate/nitrite and flow-mediated dilatation (FMD) of the brachial artery were measured pre- and postintervention. Both interventions reduced body weight (D 8.9%, DE 8.5%, time effect p < 0.001). Significant reductions in body fat, waist circumference, blood pressure, glycated haemoglobin, glucose, insulin resistance, lipids and MDA and increases in urinary nitrite/...Continue Reading

References

Jan 1, 1991·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G NoberascoL Adezati
Nov 17, 1998·Diabetes/metabolism Reviews·M L HoningT J Rabelink
Apr 8, 1999·Journal of the American College of Cardiology·P ClarksonJ E Deanfield
Feb 12, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·A LavrencicI Keber
Feb 17, 2000·The New England Journal of Medicine·R HambrechtG Schuler
Mar 22, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·M PráznýJ Hilgertová
Aug 19, 2000·Annals of Medicine·O T Raitakari, D S Celermajer
Nov 9, 2000·British Journal of Clinical Pharmacology·O T Raitakari, D S Celermajer
Feb 17, 2001·Heart·P Vallance, N Chan
Aug 31, 2001·Journal of the American College of Cardiology·A MaioranaD Green
Dec 1, 2001·Endocrinology and Metabolism Clinics of North America·O HamdyE S Horton
Jan 15, 2002·Journal of the American College of Cardiology·Mary C CorrettiUNKNOWN International Brachial Artery Reactivity Task Force
May 29, 2002·Diabetes Care·Kathryn C B TanKaren S L Lam
Sep 13, 2002·Obesity Research·Catherine P FensterRakesh P Patel
Feb 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Piero O BonettiAmir Lerman
Mar 8, 2003·Journal of Diabetes and Its Complications·Giancarlo De MattiaD Fava
Jul 26, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Joshua A BeckmanMark A Creager
Aug 23, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Daniel J GreenJ Gerard O'Driscoll
Oct 3, 2003·The American Journal of Clinical Nutrition·Mary C GannonHeidi Hoover
Nov 12, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·H HarderA Astrup
Dec 6, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Maria RaitakariOlli T Raitakari
Jan 9, 2004·Endocrinology and Metabolism Clinics of North America·Carol A Maggio, F Xavier Pi-Sunyer
Apr 15, 2004·The American Journal of Cardiology·Robert D BrookSanjay Rajagopalan
May 27, 2004·Diabetes Care·Tara M WallaceDavid R Matthews
Oct 7, 2004·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D YesilbursaC Jale
Nov 25, 2004·The Journal of Clinical Endocrinology and Metabolism·Sangeeta R KashyapRalph A DeFronzo
Jan 12, 2005·The American Journal of Cardiology·Noyan GokceCaroline M Apovian
Jul 6, 2005·The Tohoku Journal of Experimental Medicine·Oguz OzcelikHaluk Kelestimur

❮ Previous
Next ❯

Citations

Mar 5, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Nada SallamIsmail Laher
Mar 2, 2011·Wiener medizinische Wochenschrift·Christian BrinkmannKlara Brixius
Apr 30, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mika VenojärviMustafa Atalay
Jan 22, 2013·Psychiatry Research·Guillaume FondAndreas Michalsen
Jan 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·A V WitteA Flöel
Feb 19, 2011·Journal of Obesity·Kade DavisonJonathan D Buckley
Aug 29, 2012·Oxidative Medicine and Cellular Longevity·Edite Teixeira de LemosFlávio Reis
Oct 19, 2011·Experimental Diabetes Research·Saeid GolbidiIsmail Laher
Oct 15, 2013·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·N BlanchJ B Keogh
Jul 14, 2011·Oral Diseases·O A GonzálezM J Novak
Jul 8, 2011·The Journal of Obstetrics and Gynaecology Research·Robinson Ramírez-VélezPatricio López-Jaramillo
Nov 22, 2015·Scandinavian Journal of Medicine & Science in Sports·M NybergY Hellsten
Oct 6, 2015·Sports Medicine - Open·Chun-Jung HuangEdmund O Acevedo
May 21, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Adrian L Lopresti, Peter D Drummond
Aug 13, 2014·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·J MerinoL Masana
Mar 14, 2013·Menopause : the Journal of the North American Menopause Society·Jordi MerinoLluís Masana
Nov 23, 2016·The Journal of Endocrinology·Pongpan TanajakNipon Chattipakorn
Sep 7, 2011·Vascular Medicine·Amy G HuebschmannJudy G Regensteiner
May 18, 2012·Asia-Pacific Journal of Public Health·Selina Khoo, Tony Morris
Dec 14, 2017·International Journal of Environmental Research and Public Health·Permal DeoPeter M Clifton
Mar 10, 2009·Diabetes/metabolism Research and Reviews
Nov 19, 2010·Medicine and Science in Sports and Exercise·Sheri R ColbergUNKNOWN American Diabetes Association
Jul 18, 2012·The Journal of Clinical Endocrinology and Metabolism·F H J van TienenL J C van Loon
Aug 10, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Allon N FriedmanJoan Temmerman
Sep 26, 2019·Physiological Reports·Nicole M GilbertsonSteven K Malin

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