Effect of candidate vaginally-applied microbicide compounds on recognition of antigen by CD4+ and CD8+ T lymphocytes

Biology of Reproduction
Gregg N MilliganLawrence R Stanberry

Abstract

Vaginally applied antimicrobial compounds (microbicides) are being developed as an alternative method for preventing the spread of sexually transmitted diseases. In addition to identifying compounds effective against a spectrum of sexually transmitted pathogens, it will be important to ensure that these compounds are safe. Avoiding toxicity, inflammatory responses, or alteration of the function of resident immune cells are important considerations for the development of vaginally applied microbicides. Studies were performed with two classes of candidate microbicide compounds to determine if they would interfere with the recognition of antigen by CD4(+) and CD8(+) T lymphocytes. The presence of nontoxic concentrations of the anionic detergent cholic acid or the sulfated polymer lambda carrageenan did not inhibit recognition of immune peptide by antigen-specific T cells. However, antigen recognition by both CD4(+) and CD8(+) T lymphocytes was inhibited in the presence of the naphthalene sulfonate polymer PRO 2000. Brief (4-h) exposure of antigen-presenting cells or T cells to PRO 2000 did not result in inhibition of antigen uptake and processing by antigen-presenting cells or the ability of specific T cells to respond to antigen ...Continue Reading

References

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Citations

Jun 1, 2011·Drug Delivery and Translational Research·Chi H Lee
Sep 28, 2005·Expert Opinion on Investigational Drugs·Kurt Vermeire, Dominique Schols
Jul 26, 2005·Journal of Reproductive Immunology·Gregg N MilliganLawrence R Stanberry
Dec 19, 2009·Pharmaceutical Development and Technology·David R Friend

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Methods Mentioned

BETA
Assay
ELISA
enzyme-linked immunosorbent assay
Flow Cytometry
PMA

Software Mentioned

Flow Jo

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