Effect of Cannabidiol on Medial Temporal, Midbrain, and Striatal Dysfunction in People at Clinical High Risk of Psychosis: A Randomized Clinical Trial.

JAMA Psychiatry
Sagnik BhattacharyyaPhilip K McGuire

Abstract

Cannabidiol (CBD) has antipsychotic effects in humans, but how these are mediated in the brain remains unclear. To investigate the neurocognitive mechanisms that underlie the therapeutic effects of CBD in psychosis. In this parallel-group, double-blind, placebo-controlled randomized clinical trial conducted at the South London and Maudsley NHS Foundation Trust in London, United Kingdom, 33 antipsychotic medication-naive participants at clinical high risk (CHR) of psychosis and 19 healthy control participants were studied. Data were collected from July 2013 to October 2016 and analyzed from November 2016 to October 2017. A total of 16 participants at CHR of psychosis received a single oral dose of 600 mg of CBD, and 17 participants at CHR received a placebo. Control participants were not given any drug. All participants were then studied using functional magnetic resonance imaging (fMRI) while performing a verbal learning task. Brain activation during verbal encoding and recall, indexed using the blood oxygen level-dependent hemodynamic response fMRI signal. Of the 16 participants in the CBD group, 6 (38%) were female, and the mean (SD) age was 22.43 (4.95) years; of 17 in the placebo group, 10 (59%) were female, and the mean (S...Continue Reading

Associated Clinical Trials

Apr 5, 2021·Jennifer L. Robinson, Ph.D.

References

Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·L R Squire, S M Zola
Jan 1, 1997·Magnetic Resonance Imaging·M J BrammerS Rabe-Hesketh
Jul 26, 2003·NeuroImage·Ola FrimanHans Knutsson
Jun 3, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Deepak Cyril D'SouzaJohn Harrison Krystal
Mar 23, 2005·Biological Psychiatry·Deepak Cyril D'SouzaJohn Harrison Krystal
Dec 14, 2005·The Australian and New Zealand Journal of Psychiatry·Alison R YungJoe Buckby
Feb 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Björn H SchottEmrah Düzel
Jul 4, 2006·Biological Psychiatry·Martin LepageSamarthji Lal
Jan 24, 2007·NeuroImage·Bertrand ThirionJean-Baptiste Poline
Apr 7, 2007·Schizophrenia Bulletin·Andor E SimonDaniel Umbricht
Apr 10, 2007·Annual Review of Neuroscience·H EichenbaumC Ranganath
Oct 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel J Lodge, Anthony A Grace
Dec 11, 2007·Nature Neuroscience·Fiona McNab, Torkel Klingberg
Apr 2, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Celia J A Morgan, H Valerie Curran
Jun 14, 2008·Cerebral Cortex·Susan M LandauWilliam J Jagust
Jun 17, 2008·Science·Erika DahlinLars Nyberg
Oct 4, 2008·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Antonio Waldo Zuardi
Jul 18, 2009·European Archives of Psychiatry and Clinical Neuroscience·Deepak Cyril D'SouzaMohini Ranganathan
Nov 20, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sagnik BhattacharyyaPhilip K McGuire
Nov 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yanhua RenYasmin L Hurd
Sep 11, 2010·Journal of Psychopharmacology·José Alexandre S CrippaJaime Eduardo Cecílio Hallak
Oct 5, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Celia J A MorganH Valerie Curran
Feb 11, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mateus M BergamaschiJosé Alexandre S Crippa
May 4, 2011·Archives of General Psychiatry·Andrea MechelliPhilip McGuire
Jul 20, 2011·The American Journal of Psychiatry·Oliver D HowesPhilip McGuire
Oct 9, 2012·Journal of Psychopharmacology·Amir EnglundShitij Kapur
Oct 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kimberlee D'ArdenneJonathan D Cohen
Mar 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sergiy SylantyevDmitri A Rusakov

❮ Previous
Next ❯

Citations

Oct 2, 2019·The American Journal of Psychiatry·Jeffrey A LiebermanRagy R Girgis

Dec 14, 2019·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Jairo Vinícius PintoLakshmi N Yatham
Feb 20, 2020·Current Opinion in Psychiatry·Julie SchoeversF Markus Leweke
Jun 25, 2020·Environmental and Molecular Mutagenesis·Nicole M WannerChristopher Faulk
Feb 14, 2020·Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Österreichischer Nervenärzte und Psychiater·Clarissa LaczkovicsClaudia M Klier
Jun 12, 2020·Current Pain and Headache Reports·Syena SarrafpourCyrus Yazdi
Oct 3, 2020·Frontiers in Psychiatry·Grace Blest-HopleySagnik Bhattacharyya
Sep 26, 2020·Therapeutic Advances in Psychopharmacology·Edward ChesneyAmir Englund
Jun 13, 2020·Frontiers in Psychology·Marco ColizziSagnik Bhattacharyya
Jan 11, 2020·Frontiers in Psychiatry·Paolo Fusar-PoliJoaquim Radua
May 10, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Michelle Sexton
Sep 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·H P Vasantha RupasingheValtcho D Zheljazkov
Nov 20, 2019·Therapeutic Advances in Psychopharmacology·Cathy Davies, Sagnik Bhattacharyya
Oct 7, 2020·NPJ Schizophrenia·Jean AddingtonPaul Metzak
Oct 9, 2020·BMJ Case Reports·Maximus BergerGünter Paul Amminger
Jan 9, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Brandon GunasekeraSagnik Bhattacharyya
Aug 4, 2020·Epilepsy & Behavior : E&B·Rodolphe NenertJerzy P Szaflarski
Aug 15, 2019·Neurotoxicology·Stefania BonaccorsoFabrizio Schifano
Feb 9, 2021·Frontiers in Pharmacology·Albert BatallaMatthijs G Bossong
Feb 23, 2021·Cannabis and Cannabinoid Research·Saoirse E O'SullivanSteven R Laviolette
Feb 23, 2021·Frontiers in Pharmacology·Cássio Morais LossVanessa Costhek Abílio
Nov 7, 2020·Addiction Biology·Subhadip Paul, Sagnik Bhattacharyya
Apr 15, 2021·Translational Psychiatry·Lani CupoM Mallar Chakravarty
Apr 17, 2021·Journal of Psychopharmacology·Aisling O'NeillSagnik Bhattacharyya
Feb 12, 2020·Journal of the Neurological Sciences·Erik A Levinsohn, Kevin P Hill
Jul 1, 2021·Early Intervention in Psychiatry·G Paul AmmingerPatrick D McGorry
Jul 14, 2021·Psychopharmacology·Edward ChesneyPhilip McGuire
Aug 18, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yongzhou YuWei Zhang
Jun 9, 2021·Genome Biology and Evolution·Robin van Velzen, M Eric Schranz
Aug 10, 2021·Frontiers in Psychiatry·Saeed AhmedMary F Brunette

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here