Effect of cannabinoids on neural transmission in rat gastric fundus

Canadian Journal of Physiology and Pharmacology
M StorrH D Allescher

Abstract

The purpose of this study was to examine the possible role of cannabinoids on the neuromuscular function of rat gastric fundus. In addition to possible direct effects on smooth muscle, the influence of cannabinoids on contractile (cholinergic) and relaxant (non-adrenergic, non-cholinergic (NANC)) neural innervation of the rat gastric fundus was investigated in vitro. Neither anandamide (an endogenous cannabinoid receptor agonist) nor Win 55,212-2 and methanandamide (synthetic cannabinoid receptor agonists) nor AM 630 (a cannabinoid receptor antagonist) showed any effect on smooth muscle activity at baseline or after precontraction with 5-hydroxytryptamine (5-HT; 10(-7) M). Electrical field stimulation (EFS) of the smooth muscle preparation (40 V; 5 Hz) caused cholinergically mediated twitch contractions that were abolished by atropine (10(-6) M) or tetrodotoxin (TTX; 10(-6) M). Anandamide and Win 55,212-2 reduced these twitch contractions in a concentration-dependent manner, an effect that could be reversed by the cannabinoid receptor antagonist AM 630 for anandamide, but not for Win 55,212-2. When NANC relaxant neural responses (presence of atropine (10(-6) M) and guanethidine (10(-6) M)) were induced by EFS, the cannabinoid r...Continue Reading

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Citations

Feb 28, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·A SibaevM Storr
Oct 24, 2007·Molecular Neurobiology·Francisco Arias Horcajadas
Jul 16, 2003·European Journal of Pharmacology·Vera Ralevic
Sep 5, 2003·European Journal of Pharmacology·Paola NieriMaria Cristina Breschi
Sep 14, 2006·Pharmacological Reviews·Pál PacherGeorge Kunos
Jul 11, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·John R GriderBilly R Martin
May 17, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Marnie DuncanKeith A Sharkey
Jan 16, 2010·Cases Journal·Paul Hornby, Manju Sharma
Jan 9, 2003·Expert Opinion on Investigational Drugs·Giulia Di Carlo, Angelo A Izzo
Feb 2, 2010·Pharmacology & Therapeutics·Angelo A Izzo, Keith A Sharkey
Jul 2, 2010·British Journal of Pharmacology·Brady K Atwood, Ken Mackie
Feb 6, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R AbaloM I Martín
Feb 26, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M A StorrK A Sharkey
Oct 21, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y-Y LiM Storr
Sep 22, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R AbaloM Storr
Jul 11, 2006·European Journal of Pharmacology·Mehdi GhasemiAhmad Reza Dehpour
Jun 5, 2016·Asian Pacific Journal of Tropical Medicine·Omar Abdel-Salam
Oct 5, 2016·Current Treatment Options in Gastroenterology·Zachary Wilmer Reichenbach, Ron Schey
Nov 4, 2017·Cannabis and Cannabinoid Research·Jonathan GotfriedRon Schey
Aug 20, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M A StorrK A Sharkey
Oct 4, 2005·Alimentary Pharmacology & Therapeutics·M DuncanK A Sharkey
Aug 31, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B YueceM Storr
Mar 1, 2010·Expert Review of Clinical Pharmacology·Rudolf Schicho, Martin Storr
Nov 27, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Andrei SibaevMartin Storr
May 2, 2009·Inflammatory Bowel Diseases·Martin A StorrKeith A Sharkey
Aug 2, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·M StorrH D Allescher

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