Effect of capsaicin on membrane currents in cultured vascular smooth muscle cells of rat aorta

European Journal of Pharmacology
Y C LoI J Chen

Abstract

The application of capsaicin (1 microM) produced a minor relaxant effect in endothelium-denuded rat aortae. However, capsaicin caused a greater relaxation of blood vessels precontracted with high K+ or phenylephrine. The effects of capsaicin on the ionic currents were also examined in A7r5 vascular smooth muscle cells. The tight-seal whole-cell voltage clamp technique was used. Capsaicin inhibited the Ba2+ inward current (IBa) through the voltage-dependent L-type Ca2+ channel in a concentration-dependent fashion, whereas calcitonin gene-related peptide and phenylephrine produced a minor increase in IBa. Capsaicin did not alter the overall shape of current-voltage relationship of IBa. However, capsaicin (3 microM) shifted the quasi-steady-state inactivation curve of IBa to more negative membrane potential by about 5 mV. These effects of capsaicin on IBa were reversible. In addition, capsaicin had inhibitory effects on voltage dependent K+ currents. These results suggest that inhibition of the voltage-dependent L-type Ca2+ channel is involved in the capsaicin-induced relaxation of the vascular smooth muscle, whereas capsaicin-induced inhibition of voltage-dependent K+ channels might produce an increase in cell excitability.

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Citations

Mar 23, 2004·European Journal of Pharmacology·Seigo Fujimoto, Mayumi Mori
Feb 14, 2002·Biochemical Pharmacology·Sheng Nan WuHung Ting Chiang
May 30, 1997·European Journal of Pharmacology·S N WuC J Tseng
Apr 26, 2012·European Journal of Pharmacology·Jamie J HoppsMichael D Randall
Dec 20, 2005·European Journal of Pharmacology·Seigo FujimotoMitoshi Kunimatsu
Sep 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Felipa AndradeEnrique Sánchez-Pastor

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