PMID: 6168921Feb 1, 1981Paper

Effect of capsaicin pretreatment on capsaicin-evoked release of immunoreactive somatostatin and substance P from primary sensory neurons

Naunyn-Schmiedeberg's Archives of Pharmacology
R GamseS E Leeman

Abstract

Release of immunoreactive somatostatin (I-SRIF) and immunoreactive substance P (I-SP) was studied from slices prepared from upper dorsal horn (UDH) and lower dorsal plus ventral horn (LDH-VH) of rat spinal cord. Superfusion with capsaicin (10 microM) led to release of I-SRIF and I-SP from UDH slices but not from LDH-VH slices. The capsaicin-evoked release of I-SP was 6 fold higher than that of I-SRIF. A pulse of 60 mM K+ applied after the capsaicin pulse caused release of I-SRIF and I-SP from UDH as well as LDH-VH slices. Pretreatment of rats with capsaicin (125 mg/kg, s.c.) led to a nearly 40% depletion of I-SP in slices from UDH only. Capsaicin-evoked release from these slices was reduced by 81% for I-SRIF and by 79% for I-SP. Release evoked by K+ remained unchanged. These results indicate that capsaicin causes release of both I-SRIF and-I-SP and that this release is most likely restricted to primary sensory neurons. The marked reduction of the release of I-SP after systemic capsaicin pretreatment may well represent one of the, or even the reason for the insensitivity of capsaicin pretreated rats towards chemogenic pain.

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Citations

Apr 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·J SawynokF S LaBella
Nov 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·H TraurigF Lembeck
Sep 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·H TraurigF Lembeck
Jun 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·A HaraK Kisara
Jun 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, J Donnerer
Sep 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·R Gamse
May 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·R GamseJ M Lundberg
Apr 1, 1986·Pflügers Archiv : European journal of physiology·E GeisthövelE Simon
Jan 1, 1984·Pflügers Archiv : European journal of physiology·E WelkH O Handwerker
Mar 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·G Jancsó, G Such
Mar 1, 1988·Digestive Diseases and Sciences·E A MayerC Koelbel
Dec 17, 2010·Plant Cell Reports·Cesar Aza-GonzálezNeftalí Ochoa-Alejo
Apr 29, 1985·Brain Research·W L SilverJ A Maruniak
Apr 24, 1981·European Journal of Pharmacology·A Bucsics, F Lembeck
Dec 17, 1982·European Journal of Pharmacology·J W GrowcottL D Topham
Aug 27, 1985·European Journal of Pharmacology·F Lembeck, J Donnerer
May 31, 1982·Life Sciences·S H BuckT F Burks
Jan 1, 1984·Pharmacology & Therapeutics·T Hori
Jan 1, 1988·Pharmacology & Therapeutics·L A Chahl
Dec 1, 1984·Brain Research·L C Russell, K J Burchiel
Feb 9, 1995·Journal of the Autonomic Nervous System·F MartiniJ J Puizillout
Jan 5, 1995·Regulatory Peptides·M AhmedA Kreicbergs
Sep 1, 1991·Neuroscience Research·Y KuraishiM Satoh
Jan 1, 1982·Neurochemistry International·J V PriestleyA C Cuello
Oct 23, 1989·Neuroscience Letters·M Takaki, S Nakayama

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