PMID: 6161236Nov 1, 1980Paper

Effect of capsaicin pretreatment on substance P binding to synaptic vesicles

Journal of Neurochemistry
N MayerF Lembeck

Abstract

Newborn or adult rats were pretreated with 50 mg kg-1 capsaicin. At the age of 2 to 4 months, binding of 125I-labelled Tyr8-substance P to synaptic vesicles prepared from different regions of the nervous system was examined. In both groups, capsaicin pretreatment led to a significant decrease in the number of binding sites in dorsal roots and spinal cord without having an effect on affinity. This decrease parallels the depletion of the substance P content (Gamse et al., 1980) and can be explained by degeneration of primary sensory neurons in newborn treated rats and by depletion of vesicles in adult treated rats.

References

Jan 31, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·N MayerR Gamse
Dec 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·F Lembeck, P Holzer
Aug 18, 1978·Brain Research·T M JessellA C Cuello
Sep 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·R GamseF Lembeck
Mar 15, 1979·The Journal of Comparative Neurology·R P BarberS E Leeman
Jul 6, 1979·Brain Research·E TheriaultT Jessell
Apr 30, 1979·Life Sciences·Y NakataT Segawa
Aug 13, 1979·Life Sciences·R GamseF Lembeck
Oct 15, 1979·European Journal of Pharmacology·P HolzerF Lembeck
Oct 1, 1977·Journal of Neurochemistry·A C CuelloL L Iversen
Feb 25, 1977·Brain Research·V M PickelS E Leeman
Dec 1, 1977·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G PelletierA Dupont
Mar 25, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·J SzolcsányiF JOO

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Citations

Jun 1, 1993·Journal of Neurochemistry·C J MussapE Burcher
Dec 29, 1995·Annals of the New York Academy of Sciences·C Chancellor-FreelandP H Black
Oct 1, 1982·Critical Reviews in Toxicology·Y MonsereenusornP D Pezalla

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