PMID: 11341938May 9, 2001Paper

Effect of captopril on mushroom tyrosinase activity in vitro

Biochimica Et Biophysica Acta
J C Espín, H J Wichers

Abstract

The study presented here demonstrates that the antihypertensive drug captopril ([2S]-N-[3-mercapto-2-methylpropionyl]-L-proline) is an irreversible non-competitive inhibitor and an irreversible competitive inhibitor of the monophenolase and diphenolase activities of mushroom tyrosinase when L-tyrosine and L-DOPA were assayed spectrophotometrically in vitro, respectively. Captopril was rendered unstable by tyrosinase catalysis because of the interaction between the enzymatic-generated product (o-quinone) and captopril to give rise to a colourless conjugate. Therefore, captopril was able to prevent melanin formation. The spectrophotometric recordings of the inhibition of tyrosinase by captopril were characterised by the presence of a lag period prior to the attainment of an inhibited steady state rate. The lag period corresponded to the time in which captopril was reacting with the enzymatically generated o-quinone. Increasing captopril concentrations provoked longer lag periods as well as a concomitant decrease in the tyrosinase activity. Both lag period and steady state rate were dependent of captopril, substrate and tyrosinase concentrations. The inhibition of both monophenolase and diphenolase activities of tyrosinase by capt...Continue Reading

References

Nov 26, 1976·Biochimica Et Biophysica Acta·A J Schoot UiterkampH S Mason
Aug 6, 1991·Biochimica Et Biophysica Acta·J M Wood, K U Schallreuter
Nov 1, 1991·Archives of Biochemistry and Biophysics·D JayR Gleason
Oct 1, 1988·Medicinal Research Reviews·G Prota
Apr 1, 1986·The Biochemical Journal·A Andrawis, V Kahn
Jul 15, 1987·European Journal of Biochemistry·J Ricard, A Cornish-Bowden
Nov 1, 1984·British Heart Journal·J G ClelandG Gillen
Dec 14, 1994·Biochimica Et Biophysica Acta·R G Duggleby
Nov 15, 1994·The Biochemical Journal·S Naish-ByfieldP A Riley
Jan 11, 1994·Biochimica Et Biophysica Acta·J R RosF García-Cánovas
Oct 1, 1996·Journal of Molecular Evolution·J RicardM C Maurel
Aug 1, 1997·Phytochemistry·C W van GelderH J Wichers
Jan 1, 1997·Free Radical Biology & Medicine·M BartoszG Bartosz
Dec 20, 1999·Journal of Agricultural and Food Chemistry·J C Espín, H J Wichers
Dec 20, 1999·Journal of Agricultural and Food Chemistry·J C Espín, H J Wichers
Dec 20, 1999·Journal of Agricultural and Food Chemistry·J C EspínH J Wichers
Nov 7, 1996·Chemical Reviews·Edward I. SolomonTimothy E. Machonkin
Aug 1, 1961·The Biochemical Journal·G N WILKINSON
Nov 15, 2012·Neurosurgery·Anthony WigginsStephen Honeybul

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Citations

Jun 10, 2009·The Protein Journal·Shu-Bai LiLi-Ming Zhou
Sep 19, 2009·Applied Biochemistry and Biotechnology·Shu-Bai LiLi-Min Zhu
Nov 10, 2011·Applied Biochemistry and Biotechnology·Wayne C LiaoChin-Feng Chan
Jun 15, 2012·Journal of Biomolecular Structure & Dynamics·Zhi-Jiang WangGuo-Ying Qian
Jul 8, 2009·International Journal of Molecular Sciences·Te-Sheng Chang
Jan 12, 2016·Journal of Chemical Information and Modeling·Joonhyeok ChoiJunGoo Jee
Aug 9, 2015·International Journal of Biological Macromolecules·Hemachandran HridyaRamamoorthy Siva
Oct 24, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Y B RyuK H Park
Mar 17, 2007·ChemMedChem·Yovani Marrero-PonceRichard Rotondo
Dec 3, 2010·Drug Testing and Analysis·Antonio RescignoYovani Marrero-Ponce
Mar 7, 2013·Chemical Biology & Drug Design·Jinbing LiuLiangzhong Zhao
May 4, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·Alexandra D RyazanovaIrina A Slepneva
Apr 9, 2014·Expert Opinion on Drug Discovery·Eduarda MendesAna Paula Francisco
Jan 27, 2007·Journal of Enzyme Inhibition and Medicinal Chemistry·A A SabouryA A Moosavi-Movahedi
Jan 18, 2017·Journal of Enzyme Inhibition and Medicinal Chemistry·Thanigaimalai PillaiyarVigneshwaran Namasivayam
Jul 15, 2006·Phytotherapy Research : PTR·Shoukat ParvezHyunsu Bae
Nov 7, 2006·Pigment Cell Research·Francisco SolanoGhanem Ghanem
May 24, 2007·Journal of Enzyme Inhibition and Medicinal Chemistry·M AlijanianzadehA A Moosavi-Movahedi
Oct 3, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Jiang-Xing ZhuangQing-Xi Chen
Nov 22, 2019·Molecular Biology Reports·Xin DongXinqi Xu
Apr 25, 2019·MedChemComm·Katarzyna Hałdys, Rafał Latajka
Aug 25, 2006·Journal of Biomolecular Structure & Dynamics·Yong-Doo ParkJun-Mo Yang
Jan 4, 2021·Journal of Bioscience and Bioengineering·Wei-Ming ChaiShuang Song
Nov 15, 2016·International Journal of Biological Macromolecules·Yi CuiQin Wang
Oct 1, 2013·Journal of Medicinal Chemistry·Joshua A Day, Seth M Cohen
Nov 11, 2014·Journal of Agricultural and Food Chemistry·Ruili LuZengzhi Li
Nov 18, 2018·The Journal of Investigative Dermatology·Ayako TeramaeKazuyoshi Fukai

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