PMID: 8590256Jan 1, 1995Paper

Effect of captopril on ocular irritative response to topical neutral formaldehyde and YAG-laser capsulotomy in the rabbit

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
K KrootilaH Uusitalo

Abstract

Angiotensin converting enzyme (ACE) -inhibitors inhibit degradation of inflammatory mediators substance P (SP) and bradykinin, which may further stimulate the synthesis of prostaglandins. The resulting increase in inflammatory mediators in tissues is suggested to be the reason for the dry cough, involving sensory C-fiber activation, among patients receiving ACE-inhibitor therapy. In the present study, the effect of an ACE-inhibitor, captopril, on ocular irritative responses was studied in the rabbit. Intravenous captopril decreased markedly the blood pressure and the intraocular pressure (IOP) modestly. Topical neutral formaldehyde elicits an irritative response in the eye mediated through sensory neuropeptides SP and calcitonin gene-related peptide (CGRP). Following topical neutral formaldehyde, the increase in IOP and breakdown of the blood-aqueous barrier were inhibited by captopril, while miosis was not affected. Cyclic AMP (cAMP) content in the aqueous humour was increased by captopril, and this increase was inhibited by indomethacin. Following YAG-laser anterior capsulotomy, captopril inhibited the increase in IOP, breakdown of the blood-aqueous barrier and miosis. The present study demonstrates that use of short-term adm...Continue Reading

References

May 1, 1979·Experimental Eye Research·J M ButlerB R Hammond
Oct 1, 1986·Experimental Eye Research·J StjernschantzH Seppä
Aug 1, 1988·Experimental Eye Research·K Krootila
Oct 24, 1987·British Medical Journal·R W Fuller, N B Choudry
Jan 1, 1985·Journal of Ocular Pharmacology·W G UngerS R Bloom
Nov 25, 1973·Experimental Eye Research·D F Cole, W G Unger
May 29, 1981·Neuroscience Letters·A MillerI W Chubb
Jan 1, 1981·Histochemistry·S TokumitsuW H Fishman

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Citations

Apr 17, 2002·American Journal of Respiratory and Critical Care Medicine·David HardingHugh E Montgomery
Aug 16, 2008·BMC Pulmonary Medicine·Ali Reza Hosseini-KhaliliMostafa Ghanei
Jun 17, 2006·Chest·Luca Mascitelli, Francesca Pezzetta
Jul 29, 2006·Brain Research Reviews·Josef TrogerEduard Schmid
Aug 20, 2011·Alimentary Pharmacology & Therapeutics·J R A SkipworthH E Montgomery
Jul 17, 2003·European Journal of Clinical Investigation·H Montgomery

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