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Effect of carbamate thioester derivatives of methyl- and 2-chloroethyl isocyanate on glutathione levels and glutathione reductase activity in isolated rat hepatocytes

Biochemical Pharmacology

Aug 3, 1994

Kelem KassahunThomas A Baillie

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Abstract

The present study examined the effects of S-(N-methylcarbamoyl)glutathione (SMG), S-(N-methylcarbamoyl)-L-cysteine (L-SMC) and some analogs of these S-linked conjugates of methyl isocyanate (MIC) on the activity of glutathione reductase (GR) in freshly isolated rat hepatocytes and on th...read more

Mentioned in this Paper

Cysteine
Glutathione Reductase
Antineoplastic Agents
Analogs & derivatives
Glutathione-disulfide Reductase Activity
Glutathione Disulfide
S-(N-(2-chloroethyl)carbamoyl)cysteine
2-chloroethyl isocyanate
Deficiency of acetyl-CoA Acetyltransferase
Analog
Paper Details
References
  • References16
  • Citations5
12

Effect of carbamate thioester derivatives of methyl- and 2-chloroethyl isocyanate on glutathione levels and glutathione reductase activity in isolated rat hepatocytes

Biochemical Pharmacology

Aug 3, 1994

Kelem KassahunThomas A Baillie

PMID: 8068046

DOI: 10.1016/0006-2952(94)90290-9

Abstract

The present study examined the effects of S-(N-methylcarbamoyl)glutathione (SMG), S-(N-methylcarbamoyl)-L-cysteine (L-SMC) and some analogs of these S-linked conjugates of methyl isocyanate (MIC) on the activity of glutathione reductase (GR) in freshly isolated rat hepatocytes and on th...read more

Mentioned in this Paper

Cysteine
Glutathione Reductase
Antineoplastic Agents
Analogs & derivatives
Glutathione-disulfide Reductase Activity

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Paper Details
References
  • References16
  • Citations5
12

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