PMID: 3757939Sep 1, 1986Paper

Effect of carbamazepine on dopamine release and reuptake in rat striatal slices

Epilepsia
H M BarrosJ R Leite

Abstract

Carbamazepine has been shown to enhance dopaminergic agonist behavioral effects, but not to displace [3H]spiroperidol binding. To verify if carbamazepine acts presynaptically on dopaminergic neurons, reuptake and release of [3H]dopamine were measured in rat striatal slices in vitro. It was observed that carbamazepine blocked 20% of the reuptake of [3H]dopamine, while cocaine blocked 82% of the reuptake, compared with control. Carbamazepine released 62% and tyramine released 92% of the accumulated [3H]dopamine, compared with control. It was concluded that carbamazepine acts presynaptically on striatal neurons, mainly through enhancement of dopamine release. This finding can be related to some behavioral effects described for carbamazepine; however, the importance of its effects in epileptic and manic-depressive patients remains to be clarified.

References

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Citations

Feb 1, 1996·Synapse·M S Starr
Jan 1, 1987·Psychopharmacology·H M Barros, J R Leite
Jan 1, 1989·Psychopharmacology·M Elphick
Sep 1, 1992·European Journal of Pediatrics·F VianiA Romeo
Jun 19, 1992·Pharmaceutisch Weekblad. Scientific Edition·F Pisani
Jun 1, 1995·Drug and Alcohol Dependence·I D MontoyaD A Gorelick
Jul 3, 1998·European Journal of Pharmacology·V BeijaminiR Andreatini
Oct 12, 2002·Pharmacology, Biochemistry, and Behavior·Mary CarusoCraig H Kennedy
Jun 29, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S R JocaR Andreatini
Aug 13, 2004·Brain Research·Jun-Xu LiJian-Hui Liang
Mar 1, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Fernando T ConsoniRoberto Andreatini
Apr 21, 2016·Brain Research Bulletin·Rosana Camarini, Ricardo Marcos Pautassi
Jan 1, 1997·Journal of Psychopharmacology·G Sullivan, S Davis

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