PMID: 9535315Apr 16, 1998Paper

Effect of carbamazepine on pain scores of unipolar depressed patients with chronic pain: a trial of off-on-off-on design

The Clinical Journal of Pain
A KudohA Matsuki

Abstract

The purpose of this study was to evaluate the effect of carbamazepine on chronic pain in patients with major depression. Off-on-off-on carbamazepine treatment design. Department of Anesthesiology, Hirosaki University Hospital, Japan. Fifteen patients with a diagnosis of major depression and chronic pain. Depressed patients maintained on antidepressants that had failed to help depression or pain were initially placed on 450 mg carbamazepine at 150 mg three times per day. Carbamazepine was then increased until the patients experienced satisfactory relief of pain. This dose was then maintained for 3 weeks. Afterward, the medication was stopped, and a lactose placebo was administered orally three times per day for 3 weeks. Thereafter, carbamazepine was given for 3 additional weeks at the dose that previously produced satisfactory pain relief. Pain scores were assessed four times during the course of the study: before and after the first and the second treatments with carbamazepine, using a visual analog scale in which 0 represents no pain and 10 unbearable pain. The Hamilton Depression scale was used to judge improvement in the symptoms of depression. Carbamazepine produced a statistically significant reduction in the pain scores, ...Continue Reading

References

May 1, 1979·Psychosomatics·W W Weddington, D Blazer
Feb 1, 1977·Postgraduate Medical Journal·A W CraftR H Jackson
Dec 1, 1976·Australian and New Zealand Journal of Medicine·A K Chakrabarti, S K Samantaray
May 18, 1987·Life Sciences·J F LipinskiC M Waternaux
Jul 1, 1987·Journal of Affective Disorders·I G McKeithD Eccleston
Nov 1, 1988·Experimental Neurology·K J Burchiel
Aug 1, 1988·Archives of General Psychiatry·J B Williams
Jan 1, 1986·The American Journal of Psychiatry·R M PostR T Joffe
Aug 1, 1966·Archives of Neurology·B W Rockliff, E H Davis
Mar 1, 1967·Neurology·G H Fromm, J M Killian
Jan 1, 1984·Clinical Neuropharmacology·M Swerdlow
Jan 1, 1981·Postgraduate Medical Journal·J C TaylorM L Espir
Jul 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·J A Hall, S Levin

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Citations

May 9, 2006·Gastroenterology·Ray E ClouseBruce D Naliboff
Aug 2, 2003·Biological Psychiatry·Lisa C CampbellFrancis J Keefe
Apr 15, 2005·Emergency Medicine Clinics of North America·George R Hansen
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Philip J WiffenR Andrew Moore
Dec 9, 2009·Harvard Review of Psychiatry·Stephen E NicolsonTheodore A Stern
Apr 11, 2014·The Cochrane Database of Systematic Reviews·Philip J WiffenEija A Kalso

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