Effect of carbazochrome sodium sulfonate combined with tranexamic acid on blood loss and inflammatory response in patients undergoing total hip arthroplasty.

Bone & Joint Research
Yue LuoPengde Kang

Abstract

The purpose of this study was to examine the efficacy and safety of carbazochrome sodium sulfonate (CSS) combined with tranexamic acid (TXA) on blood loss and inflammatory responses after primary total hip arthroplasty (THA), and to investigate the influence of different administration methods of CSS on perioperative blood loss during THA. This study is a randomized controlled trial involving 200 patients undergoing primary unilateral THA. A total of 200 patients treated with intravenous TXA were randomly assigned to group A (combined intravenous and topical CSS), group B (topical CSS), group C (intravenous CSS), or group D (placebo). Mean total blood loss (TBL) in groups A (605.0 ml (SD 235.9)), B (790.9 ml (SD 280.7)), and C (844.8 ml (SD 248.1)) were lower than in group D (1,064.9 ml (SD 318.3), p < 0.001). We also found that compared with group D, biomarker level of inflammation, transfusion rate, pain score, and hip range of motion at discharge in groups A, B, and C were significantly improved. There were no differences among the four groups in terms of intraoperative blood loss (IBL), intramuscular venous thrombosis (IMVT), and length of hospital stay (LOS). The combined application of CSS and TXA is more effective than T...Continue Reading

References

Mar 1, 1983·Anesthesiology·J B Gross
May 1, 1995·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Y MatsumotoN Sakuragawa
Sep 11, 2002·European Journal of Pharmacology·Toshiaki SendoRyozo Oishi
May 20, 2005·Archives of Orthopaedic and Trauma Surgery·Narayana PrasadArun Mullaji
Oct 30, 2010·Vox Sanguinis·Ø JansP I Johansson
Jan 25, 2011·The Journal of Arthroplasty·Xudong LiuBingfang Zeng
Sep 3, 2011·Physiotherapy Canada. Physiothérapie Canada·Paul W StratfordSusan F Robarts
Sep 15, 2011·The Journal of Bone and Joint Surgery. American Volume·Patrick F BerginAnthony S Unger
Nov 1, 2011·International Journal of Surgery·David MoherUNKNOWN CONSORT
Nov 18, 2011·The Journal of Arthroplasty·Hossam AbdelSalamJavad Parvizi
May 26, 2012·British Journal of Anaesthesia·A ShanderD R Spahn
Jun 26, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Hitoshi Oh-okaKimio Sugaya
May 20, 2016·The Journal of Bone and Joint Surgery. American Volume·Christian Skovgaard NielsenHenrik Husted
May 29, 2016·Clinical Orthopaedics and Related Research·Kirsten L Poehling-MonaghanMark W Pagnano
Aug 25, 2016·The Journal of Arthroplasty·William K OelsnerJonathan G Schoenecker
Oct 7, 2016·The Journal of Bone and Joint Surgery. American Volume·Brian HallstromRichard E Hughes
Feb 17, 2017·British Journal of Anaesthesia·S M Goobie
Jan 3, 2018·The Bone & Joint Journal·K R BerendM J Morris
Feb 26, 2019·Bone & Joint Research·M McLeanN L Millar
Mar 28, 2019·Bone & Joint Research·P BusseS Zwingenberger
Sep 3, 2019·The Bone & Joint Journal·Kendall E BradleyMichael P Bolognesi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.