Effect of carbenoxolone on gastric prostaglandin E2 levels in patients with peptic ulcer disease following vagal and pentagastrin stimulation

European Journal of Clinical Investigation
J Rask-MadsenC Bekker

Abstract

The influence of oral carbenoxolone sodium (50 mg X 3 daily) on prostaglandin E2 release into gastric juice has been examined in nine peptic ulcer patients (duodenal ulcer, n = 6; prepyloric ulcer, n = 1; gastric ulcer, n = 2) during modified sham feeding and following bolus stimulation of acid secretion by pentagastrin (6 micrograms/kg). Carbenoxolone increased the overall mean of prostaglandin E2 concentrations in gastric juice following modified sham feeding by 32 +/- 9% (mean +/- SEM; P less than 0.02) and decreased the acidity slightly but significantly (P less than 0.05). A marked rise in prostaglandin E2 levels (46 +/- 11%; n = 5; P less than 0.02) was observed in for duodenal ulcer patients and the patient with a prepyloric ulcer responding to therapy (i.e., pain relief and ulcer healing within 4 weeks of treatment). A significant peak (P less than 0.05) related to modified sham feeding was observed only during medication, while a late gradual increase in prostaglandin E2 levels--not associated with vagal stimulation--occurred both in control and carbenoxolone experiments. No significant differences were observed following pentagastrin stimulation. The initial peak in prostaglandin E2 levels observed during medication f...Continue Reading

References

Feb 1, 1976·The Journal of Pharmacy and Pharmacology·B M PeskarB A Peskar
Dec 1, 1981·European Journal of Clinical Investigation·W D ReesG Flemström
Nov 1, 1982·Digestive Diseases and Sciences·W D ReesL A Turnberg
Jul 1, 1980·American Journal of Surgery·R P FogliaG S Rachelefsky

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Citations

Aug 1, 1993·Digestive Diseases and Sciences·A KleineB M Peskar
Feb 1, 1986·Digestive Diseases and Sciences·D E WilsonM Noar
Feb 1, 1986·Prostaglandins·B M PeskarB A Peskar
Feb 16, 1991·Lancet·M E Baker, D D Fanestil
Dec 1, 1991·British Journal of Pharmacology·A Dembinska-KiecB A Peskar
Mar 1, 1995·Clinical Pharmacology and Therapeutics·J HillingsøK Bukhave
May 1, 1990·International Journal of Biometeorology·P VogelaereS Bekaert
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·J Rask-Madsen, K Lauritsen
May 1, 1995·Journal of Cataract and Refractive Surgery·K MatsuoN Miyata
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·J Rask-Madsen
Nov 1, 1985·Journal of Clinical Pharmacology·N CharletR J Wills
Apr 1, 1991·Alimentary Pharmacology & Therapeutics·A Mertz-NielsenJ Rask-Madsen
Jan 1, 1985·Acta Medica Scandinavica·A AlyC Johansson
Jan 1, 1987·Scandinavian Journal of Gastroenterology. Supplement·A AlyC Johansson
Jul 1, 1992·Phytochemistry·S B MahatoG Roy

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