PMID: 36831Jun 1, 1979

Effect of carbon and nitrogen source additions on the development of a productive strain of P. nigricans Thom and on the level of adenylates in its mycelium

I G Rogal'E N Sokolova


Growth of the cultured strain og P. nigricans and dynamics of the adenylate levels in its mycelium on mineral media with 2 per cent of glucose were studied in relation to the means and time of addition of glucose, NaNO3 or their mixture to the medium. It was shown that the maximum yield of the mycelium could be obtained with addition of glucose once at the moment of inoculation. The mixture of glucose with NaNO3 provided even higher yields of the biomass but only with its fractional addition. Introduction of additional amounts of NaNO3 at the moment of inoculation and during the growth phase (5 days) inhibited the subsequent development of the culture providing stable levels of ATP and ADP, while introduction of NaNO3 on the 7th day stimulated the culture growth and the antibiotic yield. The use of NaNO3 in the mixture with glucose eliminated inhibition and increased the ratio of ATP to ADP and the antibiotic yield.

Related Concepts

Magnesium ADP
Adenosine Triphosphate, Chromium Ammonium Salt
Vitreous Carbon
Hydrogen-Ion Concentration

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.