Effect of carbon dioxide laser resurfacing on epidermal p53 immunostaining in photodamaged skin

Archives of Dermatology
Jeffrey S OrringerGary J Fisher

Abstract

To quantitatively examine changes in p53 tumor suppressor gene immunostaining after carbon dioxide (CO(2)) laser resurfacing of photodamaged skin to assess the potential value of this treatment in reducing the risk of progression to cutaneous carcinoma. Serial in vivo immunohistochemical analyses after laser therapy. Academic referral center, Department of Dermatology, University of Michigan, Ann Arbor. Volunteer sample of 11 adults, 51 to 76 years old, with clinically evident photodamage of the forearms. Focal CO(2) laser resurfacing of photodamaged forearms and serial biopsies at baseline, 3 weeks, and 6 months after treatment. Because keratinocytes with mutations in p53 or altered p53 expression stain via immunohistochemical techniques, image analysis of immunohistochemically stained sections was used to quantify p53 expression. Positive immunostaining for p53 in the interfollicular epidermis was noted in 8 of 11 subjects at baseline, with an average staining density of 250 cells/mm(2). Average staining decreased to 3 cells/mm(2) 3 weeks after treatment. This decrease was sustained at 5 cells/mm(2) 6 months after resurfacing. There was a consistent decrease in p53 immunostaining in the interfollicular epidermis lasting for a...Continue Reading

Citations

May 21, 2008·Archives of Dermatology·Gary J FisherJohn J Voorhees
Mar 6, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Moetaz El-DomyatiJouni Uitto
Sep 16, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Sang Eun LeeSung Bin Cho
Mar 19, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Sung Bin ChoJu Hee Lee
Jan 31, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Judith U OstertagGertruud A Krekels
Mar 19, 2011·Journal of the American Academy of Dermatology·Do-Sang JungKyung-Sool Kwon
Dec 16, 2000·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·E SharonM Ulmansky
Jul 3, 2015·JAMA Facial Plastic Surgery·Paul J CarniolEric T Carniol

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