PMID: 6981417Jun 1, 1982Paper

Effect of carbon monoxide on atherogenesis in normal pigs and pigs with von Willebrand's disease

Atherosclerosis
D L SultzerT R Griggs

Abstract

The extent of coronary and aortic atherosclerosis was examined in pigs following balloon-catheter injury of coronary arteries and subsequent feeding of an atherogenic diet for 4 months. The pigs were either exposed intermittently to 100 ppm carbon monoxide or to ambient air alone. Three types of pigs were used: normals, homozygotes for von Willebrand's disease (bleeders), and heterozygotes (carriers). The 3 types of pigs developed coronary artery intimal lesions of similar thickness. Aortic lesions, quantified as percent of aortic surface involved with sudanophilia and raised fibrous plaques, were slightly less extensive in bleeder pigs than in normals. Carbon monoxide exposure did not increase the thickness of coronary artery intimal lesions, nor did it increase the percent of aortic surface involved with sudanophilia or raised fibrous lesions. These results suggest that exposure to low levels of carbon monoxide does not perceptibly enhance atherogenesis induced by hypercholesterolemia. None of 14 bleeder pigs showed evidence of myocardial infarction, despite significant coronary artery narrowing. Of the 24 normal and carrier pigs, 5 showed myocardial infarction. Four of these 5 pigs were exposed to carbon monoxide, while 1 wa...Continue Reading

References

Jul 1, 1979·Archives of Environmental Health·L C Becker, E D Haak
Feb 4, 1978·British Medical Journal·M HeliövaaraS Punsar
Aug 12, 1976·The New England Journal of Medicine·R Ross, J A Glomset
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Citations

Jan 1, 1994·Journal of Applied Toxicology : JAT·D G PenneyE M Van Egmond
Mar 1, 1993·Atherosclerosis·C J Smith, T J Steichen
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D A BellingerT R Griggs
Jun 1, 1993·Journal of Toxicology and Environmental Health·D G PenneyE M Van Egmond
Nov 1, 1991·Environmental Health Perspectives·D G Penney, J W Howley
Nov 1, 1983·Progress in Cardiovascular Diseases·S Niewiarowski, A K Rao
Jul 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R L ReddickT R Griggs
Jan 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·V FusterE J Bowie
May 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·T C NicholsT R Griggs
Mar 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M CattaneoP M Mannucci

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