Effect of carbonated beverages and of an antiemetic containing carbohydrate and phosphoric acid on riboflavin bioavailability and salicylamide biotransformation in humans.

Journal of Pharmaceutical Sciences
J B Houston, G Levy

Abstract

Two carbohydrate-phosphoric acid solutions, one a widely used beverage (Solution C) and the other a pharmaceutical product used as an antiemetic (Solution E), administered together with riboflavin-5'-phosphate or salicylamide to healthy human adults, significantly increased the bioavailability of riboflavin and appreciably altered the metabolic fate of salicylamide (increased conversion to the sulfate and decreased formation of the glucuronide). A beverage containing phosphoric acid but no carbohydrates (Solution T) also increased the bioavailability of riboflavin but not as much as Solution C. These effects are attributed to a decrease of the gastric emptying rate caused by carbohydrates and phosphoric acid, consistent with the empirical use of Solution C syrup and Solution E as antinauseants and antiemetics. The results demonstrate also that the choice of beverage to be taken with medication can affect the bioavailability and/or metabolic fate of medicinals with saturable absorption and/or biotransformation characteristics.

Citations

Aug 1, 1976·Journal of Pharmaceutical Sciences·F W Goodhart, M L Eichman
Sep 23, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Alfredo García-Arieta
Oct 28, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jens Van Den AbeelePatrick Augustijns
Apr 1, 1988·Journal of Pharmaceutical Sciences·S R HowellC D Klaassen
Jan 1, 1976·Annals of the New York Academy of Sciences·G Levy
Jan 1, 1976·Annals of the New York Academy of Sciences·A Hurwitz, D L Azarnoff
Aug 1, 1980·Archiv der Pharmazie·S EbelB Missler

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