Effect of carcinogens and analogs on interferon induction

Oncology
M C BarnesG Sonnenfeld

Abstract

Pretreatment of mouse embryo fibroblasts with several chemicals, including 7,12-dimethylbenz-(a)-anthracene, 2-aminofluorene, aflatoxin B1, benzo-(a)-pyrene, styrene oxide, and the No. 4 fraction of tobacco smoke condensate, resulted in severely reduced production of interferon when the cells were challenged with Newcastle disease virus. All of the above chemicals are proven or strongly suggested carcinogens. When the analogs methyl methanesulfonate, a potent carcinogen, and ethyl methanesulfonate, a weak carcinogen, were applied to cells, interferon induction was only inhibited by the methyl methanesulfonate. Therefore, carcinogens may directly inhibit the induction of interferon by Newcastle disease virus.

Citations

Jan 1, 1984·Journal of Interferon Research·G SonnenfeldU N Streips
Apr 1, 1986·Journal of Interferon Research·G D GriffinW M Mitchell
Oct 1, 1986·Journal of Interferon Research·N Hahon, J A Booth
Mar 15, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Carla M T BauerKaren L Mossman
Apr 1, 1986·Environmental Research·N HahonM J Sepulveda
Feb 1, 1987·Environmental Research·G Sonnenfeld, A M Rose
Jun 1, 1985·Environmental Research·D K DeLor, G Sonnenfeld
Feb 1, 1983·Environmental Research·N Hahon
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Jan 1, 1984·Journal of Interferon Research·K A Golemboski, G Sonnenfeld
Feb 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·M Degré, M Holberg-Petersen

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