PMID: 6160341Jan 1, 1981Paper

Effect of cardiac beta-adrenergic blockade or denervation on cardiotoxicity of digoxin and an aminosugar cardenolide

Journal of Cardiovascular Pharmacology
S K PuryearR W Caldwell

Abstract

This study examined the role of cardiac beta-adrenergic receptors and cardiac sympathetic and vagal nerves in the cardiotoxicity of 3-beta-0-(4-amino-4,6-dideoxy-beta-D-glucopyranosyl) digitoxigenin hydrochloride (ASI-254). Vagally intact dogs received a constant rate intravenous infusion of either digoxin or ASI-254 in the presence and absence of practolol. Practolol pretreatment increased the dose of digoxin required to produce arrhythmias and markedly altered the pattern of toxicity, but did not alter the lethal dose. The terminal event was cardiac standstill rather than ventricular fibrillation as seen in digoxin control dogs. Practolol did not alter the toxic dose of ASI-254 and produced little change in the pattern of cardiotoxicity; both control and practolol-treated dogs died in cardiac standstill. Surgical sympathectomy did not alter the toxic dose of ASI-254, the character of toxicity, or the lethal dose compared to neurally intact dogs. However, vagal innervation may play a role in determining the type of cardiotoxicity produced by ASI-254. Vagotomy alone did not alter the toxic or the lethal dose of ASI-254; vagotomy did, however, alter the character of cardiotoxicity and terminal event. Our results indicate that AS...Continue Reading

Citations

Sep 1, 1992·Journal of Clinical Anesthesia·P M Heerdt, M E Heerdt
Dec 1, 1984·Circulation Research·R W CaldwellS L Bealer
Jan 1, 1988·Reviews in Clinical & Basic Pharmacology·C M LathersH Klions

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