Effect of cardiopulmonary bypass on activated partial thromboplastin time waveform analysis, serum procalcitonin and C-reactive protein concentrations.

Critical Care : the Official Journal of the Critical Care Forum
Bertrand DelannoyMaxime Cannesson

Abstract

Systemic inflammatory response syndrome (SIRS) is a frequent condition after cardiopulmonary bypass (CPB) and makes conventional biological tests fail to detect postoperative sepsis. Biphasic waveform (BPW) analysis is a new biological test derived from activated partial thromboplastin time that has recently been proposed for sepsis diagnosis. The aim of this study was to investigate the accuracy of BPW to detect sepsis after cardiac surgery under CPB. We conducted a prospective study in American Society of Anesthesiologists' (ASA) physical status III and IV patients referred for cardiac surgery under CPB. Procalcitonin (PCT) and BPW were recorded before surgery and every day during the first week following surgery. Patients were then divided into three groups: patients presenting no SIRS, patients presenting with non-septic SIRS and patients presenting with sepsis. Thirty two patients were included. SIRS occurred in 16 patients (50%) including 5 sepsis (16%) and 11 (34%) non-septic SIRS. PCT and BPW were significantly increased in SIRS patients compared to no SIRS patients (0.9 [0.5-2.2] vs. 8.1 [2.0-21.3] ng/l for PCT and 0.10 [0.09-0.14] vs. 0.29 [0.16-0.56] %T/s for BPW; P < 0.05 for both). We observed no difference in peak...Continue Reading

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Citations

Oct 31, 2012·Journal of Anesthesia·Vinoth Sankar, Nigel R Webster
Oct 5, 2012·Clinical Microbiology Reviews·Konrad ReinhartChristiane S Hartog
Feb 4, 2010·Critical Care : the Official Journal of the Critical Care Forum·Christian P SchneiderWolfgang H Hartl
Nov 26, 2010·Critical Care : the Official Journal of the Critical Care Forum·Aurélie CheronGuillaume Monneret
Mar 17, 2012·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Iolanda Jordan GarciaAntonio P Rico
Aug 24, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·J-J LehotO Bastien
Jul 14, 2010·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·D Crespo-MarcosD Pérez-Solís
Mar 8, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Gianluca Paternoster, Fabio Guarracino
Sep 7, 2017·International Journal of Laboratory Hematology·P O Sevenet, F Depasse
Apr 28, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Susan E SmithJulie Kalabalik-Hoganson
Oct 23, 2015·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Iris M MandellRobinder G Khemani

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