PMID: 85053Mar 3, 1979Paper

Effect of cardioselective and non-selective beta-blockade on the hypoglycaemic response in insulin-dependent diabetics

I LagerU Smith


The response to intravenous insulin was studied in seven diabetics after a dose of placebo, propranolol (40 mg), or metoprolol (50 mg). Two of the seven subjects also had a week's course of each of the same agents taken three times daily. Neither of the beta-blockers potentiated the effect of insulin as judged by the rate of reduction in blood-glucose. However, blood-glucose recovery was reduced significantly by propranolol, but not significantly by metoprolol. Propranolol caused severe bradycardia and raised diastolic blood-pressure during hypoglycaemia; these effects were milder with metoprolol. Propranolol inhibited the free-fatty-acid levels after hypoglycaemia to a greater extent than did metoprolol. The results strongly suggest that propranolol (and presumably other non-selective beta-blockers) is hazardous in subjects prone to hypoglycaemia. When diabetics require beta-blockade a cardioselective beta 1-blocker should be used.


Jul 31, 1976·British Medical Journal·S P Deacon, D Barnett
Jan 1, 1977·Scottish Medical Journal·N M DavidsonE B French
Dec 28, 1977·European Journal of Clinical Pharmacology·C L van HerwaardenA van't Laar
Mar 1, 1977·The Journal of Clinical Endocrinology and Metabolism·J W BensonJ W Ensinck
Jul 1, 1970·Metabolism: Clinical and Experimental·W G Blackard, G J Hubbell

❮ Previous
Next ❯


Jul 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·T LindströmH J Arnqvist
Apr 1, 1985·Drug Intelligence & Clinical Pharmacy·G A Mills, J R Horn
Dec 1, 1987·Anaesthesia·A B ChannaM H Sheikh
Jan 1, 1986·Current Medical Research and Opinion·D M FraserJ D Poloniecki
Jan 19, 1984·The New England Journal of Medicine
Jan 1, 1983·Acta Medica Scandinavica. Supplementum·U Smith
Jan 1, 1983·Acta Medica Scandinavica. Supplementum·G Holm
Mar 1, 1982·Journal of Clinical and Hospital Pharmacy·M J KendallD J Worthington
Mar 20, 2010·International Journal of Clinical Practice·A H BarnettA Middleton
Feb 28, 2018·American Journal of Physiology. Endocrinology and Metabolism·Candace M RenoSimon J Fisher
Sep 27, 1979·The New England Journal of Medicine·J Koch-Weser
Mar 1, 1986·Pharmacotherapy·J Wikstrand
Jul 25, 1985·The New England Journal of Medicine·P E Cryer, J E Gerich
Oct 1, 1980·European Journal of Clinical Investigation·U Smith
Apr 1, 1982·British Journal of Clinical Pharmacology·R ZamanP I Biggs
Nov 1, 1985·Anaesthesia·R I MeekeJ D Gaffney
Apr 2, 1983·British Medical Journal·A Breckenridge
Jan 1, 1993·European Journal of Clinical Investigation·P G NewrickR J Corrall
Mar 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·W Y Tse, M Kendall
Jul 17, 2001·Journal of Internal Medicine·P T Sawicki, A Siebenhofer
Jun 15, 2007·Journal of Hypertension·Peter M Nilsson
Oct 1, 1986·Scottish Medical Journal·R J NorthcoteD Ballantyne
Jan 1, 1983·Acta Medica Scandinavica. Supplementum·I Lager
Nov 1, 1985·Hypertension·B N TrostC Beretta-Piccoli
Nov 1, 1990·British Journal of Clinical Pharmacology·A J SinclairS J Warrington
Jan 1, 1984·European Journal of Clinical Pharmacology·K TöttermanF Fyhrquist
Apr 5, 1980·British Medical Journal·A H BarnettP J Watkins
Feb 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·J FowelinI Lager

❮ Previous
Next ❯

Related Concepts

Related Feeds


Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.