PMID: 6160346Jan 1, 1981Paper

Effect of carotid sinus baroreceptor reflex on responses to phenylephrine and nitroprusside in anesthetized cats

Journal of Cardiovascular Pharmacology
C V Greenway, I R Innes

Abstract

This study attempted to measure the extent to which the carotid sinus baroreceptor reflex attenuates the acute changes in arterial pressure during infusions of phenylephrine and nitroprusside, and to express these effects as equations which could be used in a simple computer model of the circulation. Arterial pressure and cardiac output were measured in vagotomized cats anesthetized with chloralose or pentobarbital. The carotid arteries were perfused to allow sinus pressure either to follow changes in systemic arterial pressure or to be held at the preinfusion control level, thereby eliminating the effects of the reflex. There was a linear relationship between arterial pressure in the presence and absence of the reflex, and the changes in arterial pressure were attenuated to one-third by the reflex while cardiac output was not significantly changed. These effects are described by simple equations involving peripheral resistance, heart rate, and venous compliance. The activity of the reflex was not significantly different in cats anesthetized with pentobarbital or chloralose, and our data do not support the view that these anesthetic agents depress the vasomotor component of the carotid sinus reflex.

Citations

May 1, 1987·Medical & Biological Engineering & Computing·R BurattiniN Westerhof
Jan 1, 1983·Hypertension·A M ShepherdT K Keeton
Mar 18, 2000·Canadian Journal of Physiology and Pharmacology·G Castañeda-Hernández, V Granados-Soto
Apr 25, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Jaime EugenínPatricio Zapata
May 18, 1999·The American Journal of Physiology·C HanW W Lautt

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