Effect of carryover of clot activators on coagulation tests during phlebotomy

American Journal of Clinical Pathology
Yoko FukugawaTakashi Watanabe

Abstract

We investigated the effect of clot activators carried over from the serum tube on major coagulation tests during phlebotomy. First, blood specimens from 30 normal subjects were mixed with small amounts of fluid containing clot activators, and their effects on various coagulation tests were determined. Only the value of fibrin monomer complex displayed a remarkable change when thrombin-containing fluid was added to the blood specimens. Subsequently, 100 paired blood specimens (taken from 75 healthy volunteers and 25 patients taking warfarin) were collected in coagulation tubes before and after the serum tube using standard phlebotomy procedures. Various coagulation tests were performed to determine the effect of contamination of thrombin-containing blood on coagulation parameters. Differences between the 2 tubes were minimal but significant for some of the coagulation tests. Therefore, we conclude that the effect of clot activators in the serum tube on coagulation tests is minimal when standard phlebotomy procedures are used.

References

Jun 1, 1997·American Journal of Clinical Pathology·E L Gottfried, M M Adachi
Apr 5, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fred C Tenover, Robert C Moellering
Feb 26, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Kristi J SmockChristopher M Lehman

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Citations

Nov 26, 2013·Biochemia Medica·Nora NikolacUNKNOWN Croatian Society of Medical Biochemistry and Laboratory Medicine
Sep 11, 2016·Clinical Biochemistry·Dorothy M AdcockGiuseppe Lippi
Jul 23, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Michael CornesUNKNOWN Working Group for Preanalytical Phase (WG-PRE), European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)
Feb 11, 2021·International Journal of Environmental Research and Public Health·Giacomo BazzanoDario Laquintana

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