Effect of cat and daycare exposures on the risk of asthma in children with atopic dermatitis.

Allergy and Asthma Proceedings
Jonathan M GaffinWanda Phipatanakul

Abstract

Atopic dermatitis (AD) in young children is often followed by the development of asthma (atopic march). The role of environmental exposures is unclear in this high-risk population. We aimed to determine the predictive relationship between indoor allergen exposures, particularly pets, rodents, and cockroaches, to the development of asthma in a prospective pediatric cohort. Children with AD and a family history of allergy were followed prospectively with questionnaire ascertainment of environmental exposure to cats, dogs, cockroaches, rats, and mice. Asthma was diagnosed by study physicians based on caregiver reports of symptoms continually assessed over the course of the study period. Fifty-five of the 299 children developed asthma by the end of the study. Cat exposure had a strong and independent effect to reduce the risk of developing asthma across all analyses (odds ratio [OR], 0.16; 95% confidence interval [CI], 0.05-0.53). Dog, mouse, rat, and cockroach exposures did not significantly influence the development of asthma. Daycare exposure had the largest risk reduction for the development of asthma (OR, 0.08; 95% CI, 0.03-0.19). Maternal asthma (OR, 2.93; 95% CI, 1.29-6.67), baseline body mass index (OR, 1.23; 95% CI, 1.08-1...Continue Reading

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Citations

Aug 11, 2012·Current Allergy and Asthma Reports·Shyamali C DharmageAdrian J Lowe
Jun 22, 2014·International Immunopharmacology·Jonathan M GaffinWanda Phipatanakul
Oct 14, 2014·International Immunopharmacology·Jonathan M GaffinWanda Phipatanakul
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Jan 23, 2019·Clinical Reviews in Allergy & Immunology·Pavadee PoowuttikulDivya Seth
Jan 1, 2019·Archives of Environmental & Occupational Health·Akiko TokinobuHiroyuki Doi

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