Effect of catecholamine depletion on myocardial infarct size in dogs: role of catecholamines in ischemic preconditioning

Cardiovascular Research
R S Vander HeideK A Reimer

Abstract

Cardioprotective adaptation to brief periods of ischemia and reperfusion is termed ischemic preconditioning (PC). Limitation of infarct size by preconditioning is associated with marked slowing of ischemic metabolism. The cause of metabolic slowing has not been determined but may involve either pro- or anti-adrenergic mechanisms. Hypothetically, adrenergic stimulation could signal the adaptive response. Alternatively, metabolic slowing during the sustained ischemic challenge could occur through a reduction in beta-adrenergic stimulation. This study was designed to test the role of cardiac norepinephrine (NE) in PC. The effect of PC on myocardial infarct size was studied in control dogs and dogs depleted of catecholamines by pretreatment with reserpine (RES; 0.25 mg/kg i.v.). PC was induced by four cycles of 5 min of ischemia and 5 min of reperfusion. Infarcts were produced by 60 min of ischemia and 3 h of reperfusion. Cardiac NE depletion was verified by radioimmunoassay of tissue samples and by absence of hemodynamic response to a tyramine bolus (1.4 mg/kg) administered at the end of each experiment. Infarct size, expressed as percent of area at risk, was controlled for variation in collateral blood flow using analysis of cova...Continue Reading

Citations

Jan 1, 1997·Cardiovascular Drugs and Therapy·J W de JongS Bradamante
May 18, 2006·Basic Research in Cardiology·Robert T MalletH Fred Downey
Aug 3, 2007·Autonomic Neuroscience : Basic & Clinical·Toru KawadaMasaru Sugimachi
Sep 15, 2004·European Journal of Pharmacology·Efstathios K IliodromitisDimitrios Th Kremastinos
Jul 15, 2017·World Journal of Cardiology·John G KingmaJacques R Rouleau
Sep 30, 1996·Annals of the New York Academy of Sciences·K A Reimer

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