Effect of catecholamine-receptor stimulating agents on blood pressure after local application in the nucleus tractus solitarii of the medulla oblongata

European Journal of Pharmacology
P ZandbergD De Wied

Abstract

The effect of various catecholamines and alpha-mimetics, given by microinjection in the A2-region of the nucleus tractus solitarii (NTS), on blood pressure was investigated in anesthetized male rats. A dose-dependent decrease of blood pressure and heart rate was induced by adrenaline as the most effective drug, followed by noradrenaline, dopamine, alpha-methylnoradrenaline and octopamine. Ablation of the rostral or caudal part of the NTS, or removal of the area postrema did not diminish the effect of alpha-methylnoradrenaline. Higher doses of noradrenaline and alpha-methylnoradrenaline caused an initial rise of blood pressure, while the blood pressure lowering effect of noradrenaline was diminished, and that of alpha-methylnoradrenaline and dopamine delayed. Isoprenaline and the (+)-stereoisomers of noradrenaline and alpha-methylnoradrenaline were ineffective. The hypotensive effect of dopamine was not prevented by systemic injection of the dopamine beta-hydroxylase inhibitor FLA 63. Prior application of haloperidol, yohimbine and phentolamine antagonized the hypotensive response to dopamine and alpha-methylnoradrenaline. Application of peripherally effective alpha-mimetics into the A2-region had no or little effect, while high...Continue Reading

References

Nov 3, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·K StarkeH D Taube
Dec 1, 1976·British Journal of Pharmacology·M D Day, A G Roach
Sep 1, 1977·Life Sciences·S Berthelsen, W A Pettinger
Sep 3, 1976·Brain Research·D H VersteegM Palkovits
Jul 1, 1976·European Journal of Pharmacology·J LipskiE Solnicka
Apr 1, 1975·Circulation Research·J P Chalmers
Mar 1, 1975·European Journal of Pharmacology·H A Struyker Boudier, A D Bekers
Apr 30, 1976·Brain Research·J Van der GugtenD H Versteeg
Jul 26, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·A PhilippuH Przuntek
May 1, 1970·Life Sciences·N E AndénT H Svensson
Oct 1, 1973·European Journal of Pharmacology·J N SinhaH Schmitt
Nov 1, 1974·European Journal of Pharmacology·W de Jong
Jan 1, 1964·Acta Physiologica Scandinavica. Supplementum·C J CLEMEDSON, A JOENSSON
Feb 9, 1965·Zeitschrift für Zellforschung und mikroskopische Anatomie·K FUXE

Citations

Apr 30, 1979·Pflügers Archiv : European journal of physiology·B Shalita, S Dikstein
Oct 29, 1986·Brain Research·A D LoewyW B Sawyer
Jun 16, 1982·European Journal of Pharmacology·W L SmithM D Adams
Aug 5, 1983·European Journal of Pharmacology·J D JohnsonG E Isom
Aug 27, 1985·European Journal of Pharmacology·E P Schoener, D K Pitts
Mar 26, 1991·European Journal of Pharmacology·R E GomezD J Reis
Mar 1, 1980·Pharmacology, Biochemistry, and Behavior·M GallagherP R Rapp
Feb 1, 1985·Journal of the Autonomic Nervous System·P R Howe
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·L J SieverD L Murphy
Sep 1, 1993·Progress in Neuro-psychopharmacology & Biological Psychiatry·K K TangriM Husain
Jan 1, 1996·Progress in Neurobiology·A J Lawrence, B Jarrott
Aug 1, 1996·Progress in Neurobiology·Y MisuH Okamura
Jan 1, 1981·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·M B Cordeiro de Sousa, A Hoffmann
May 1, 1982·Brain Research Bulletin·A R Granata, G N Woodruff
Apr 1, 1983·Brain Research Bulletin·D P Healy, J Y Jew
Jun 1, 1989·Brain Research Bulletin·W N Henley, L L Bellush
Aug 19, 1999·Brain Research Bulletin·C Farsang, J Kapocsi
Oct 1, 1993·Clinical and Experimental Pharmacology & Physiology·K TsudaY Masuyama
Jul 23, 1999·Annals of the New York Academy of Sciences·Pascal BousquetJosiane Feldman
Jan 1, 1986·Clinical and Experimental Hypertension. Part A, Theory and Practice·M J Meldrum, T C Westfall
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·H KawabeT Saruta
Mar 2, 2010·Autonomic Neuroscience : Basic & Clinical·Waldyr M OlivaBenedito H Machado
Dec 9, 2008·Autonomic Neuroscience : Basic & Clinical·Cristiane BusnardoF M A Corrêa
Mar 11, 2008·Experimental Physiology·S Kasparov, A G Teschemacher
Feb 9, 2006·Autonomic Neuroscience : Basic & Clinical·Guata Yoro SyJosiane Feldman
Dec 15, 2010·Autonomic Neuroscience : Basic & Clinical·F H F AlvesF M A Corrêa
Aug 1, 1995·Clinical and Experimental Hypertension : CHE·M TozawaK Fukiyama
Aug 1, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D R Fior-Chadi, K Fuxe
Jan 1, 1989·Circulation Research·C J TsengD Robertson
Jan 1, 1993·Circulation Research·R Mosqueda-GarciaR M Robertson
Nov 1, 1984·Hypertension·M van den BuuseW de Jong
Sep 1, 1982·Journal of Autonomic Pharmacology·M F Lokhandwala, R J Barrett
Nov 9, 2002·Journal of Neurophysiology·David D KlineDiana L Kunze
Aug 1, 1984·The British Journal of Psychiatry : the Journal of Mental Science·T H CornS A Checkley
Jan 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·S A CheckleyE Shur
Sep 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·A Jean
Apr 1, 1981·The Journal of Pharmacy and Pharmacology·B Persson
Dec 11, 2019·Pharmacological Reviews·Pascal BousquetJun-Xu Li
Jan 7, 2017·Clinical Science·Sinan Khor, Dongsheng Cai

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Metazoa
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