PMID: 9178180May 1, 1997Paper

Effect of cationic surfactant on transport of model drugs in emulsion systems

The Journal of Pharmacy and Pharmacology
X A Yoon, D J Burgess

Abstract

Excess surfactant present in emulsions can influence the rates of transport of incorporated drugs by micellar solubilization, alteration of the partitioning process and by drug-surfactant complexation. Cetyltrimethylammonium bromide (CTAB), a cationic surfactant was selected to investigate these phenomena as it forms relatively stable mineral oil-water (O-W) emulsions and has the potential for ionic interaction. Phenylazoaniline, benzocaine, benzoic acid and phenol were chosen as model drugs for this study. The emulsion critical micelle concentration (CMC) for CTAB determined using a combination of a membrane equilibrium technique and surface-tension measurement was 1.0% w/v in 10% v/v% O-W emulsion systems. Ionic interaction between model drugs and surfactants and drug hydrophobicity affected their transport rates in the emulsion systems. The transport rates of the lipophilic drugs (benzocaine and phenylazoaniline) and the ionized hydrophillic drug (benzoic acid, pH 7.0) in the emulsion systems increased with increasing CTAB concentration up to 0.5% w/v micellar concentration and then decreased at higher concentrations. The rate of transport of phenol was not affected by the presence of micellar phase. Ionic interaction betwee...Continue Reading

References

Jan 1, 1982·Journal of Pharmaceutical Sciences·G E AmidonN F Ho
Mar 1, 1996·Pharmaceutical Research·K A Yoon, D J Burgess

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Citations

May 14, 1999·Pharmaceutical Science & Technology Today·X PepinG Couarraze
Jul 29, 1998·The Journal of Pharmacy and Pharmacology·K A Yoon, D J Burgess
Jan 11, 2013·International Journal of Toxicology·Lillian C BeckerF Alan Andersen

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