Effect of CDA-II, urinary preparation, on lipofuscin, lipid peroxidation and antioxidant systems in young and middle-aged rat brain

The American Journal of Chinese Medicine
W C LinM C Liau

Abstract

The levels of lipofuscin and lipid peroxidation reflect the degree of free radical-induced oxidative damage in the brain. We examined the effects of CDA-II, a preparation of human urine, on lipofuscin and lipid peroxidation in the brain of young (3.5 months) and middle-aged rats (17 months). The rats were given CDA-II orally at dosages of 0.3 or 1.0 g/kg daily for 8 weeks. CDA-II significantly suppressed the contents of lipofuscin and lipid peroxidation in both young and middle-aged rats. CDA-II also elevated the activity of superoxide dismutase, and the amounts of glutathione and ascorbic acid in the middle-aged rats, but not in the young ones. Our results suggest that the protection against oxidative damage by CDA-II in the young rat brain may be due to its scavenging activity against free radicals. In the middle-aged rats, in addition to the scavenging activity, the levels of endogenous antioxidants were also enhanced by the CDA-II treatment.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jun 1, 1992·Journal of Nutritional Science and Vitaminology·L A SantiagoA Mori
Apr 1, 1991·Mechanisms of Ageing and Development·I SemseiA Richardson
Jun 19, 1989·Neuroscience Letters·V RavindranathH K Anandatheerthavarada
May 1, 1974·The Journal of Nutrition·D G HafemanW G Hoekstra
Jan 1, 1968·Journal of Gerontology·W ReichelB L Strehler
Jul 1, 1993·British Medical Bulletin·P H Evans
Jan 1, 1995·Journal of Cellular Biochemistry. Supplement·H L Newmark, C W Young
Jan 1, 1996·Free Radical Biology & Medicine·D Yin
Feb 7, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·E Y SözmenN I Hariri
Sep 1, 1999·The American Journal of Chinese Medicine·T Y LaiW C Lin
Sep 22, 2000·The American Journal of Chinese Medicine·W C LinY E Wu

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Citations

Nov 22, 2005·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Chih-Jung YaoShuang-En Chuang
Sep 2, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jian HuangJie Jin
Oct 25, 2011·Sports Medicine, Arthroscopy, Rehabilitation, Therapy & Technology : SMARTT·Wei-Ya Hao, Yan Chen

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