PMID: 6168928Jun 1, 1981Paper

Effect of CDP-choline on the biosynthesis of nucleic acids and proteins in brain regions during hypoxia

Neurochemical Research
I SerraA M Giuffrida

Abstract

The effect of CDP-choline on the in vivo incorporation of labeled precursors into DNA, RNA, and proteins in cerebral hemispheres, cerebellum, and brainstem of guinea pigs after hypoxic treatment was studied. The labeling of macromolecules extracted from the various subcellular fractions of these brain regions was also determined. Hypoxic treatment affected macromolecular labeling to a different extent in the three brain regions examined. CDP-choline treatment was not able to reverse the effect of hypoxia on DNA labeling, but it was able to remove the effect of hypoxia on RNA and protein labeling. The action of CDP-choline was particularly evident on the labeling of RNA in nuclei and mitochondria of the cerebellum and on the labeling of proteins in microsomes of the three brain regions examined.

References

Feb 13, 1976·Brain Research·G PalladiniL Medolago-Albani
Feb 1, 1979·Journal of Neurochemistry·M RigouletM Vandendreissche
Aug 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·G BenziA Agnoli
Sep 1, 1974·Acta Physiologica Scandinavica·V MacmillanB K Siesjö
Jun 1, 1973·Acta Physiologica Scandinavica·L D LewisB K Siesjö
Feb 15, 1974·Experientia·S ManakaH Sekino
Sep 1, 1969·Experimental Neurology·L C MassopustR J White
Apr 1, 1972·Journal of Neurochemistry·T E DuffyO H Lowry
Mar 1, 1966·Journal of Neurophysiology·R M EcclesT Oshima
Jul 1, 1966·Journal of Neurochemistry·P Mandel, S Edel-Harth
May 1, 1981·Neurochemical Research·I SerraA M Giuffrida
Mar 1, 1963·The Journal of Cell Biology·A HAMBERGER, H HYDEN
Dec 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·D E WOOLLEY, P S TIMIRAS

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Citations

Jul 1, 1989·Neurochemical Research·D F CondorelliA M Giuffrida Stella
May 1, 1994·Archives of Gerontology and Geriatrics·F PiccoliM Fioravanti
Feb 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R F VillaA M Giuffrida-Stella
Jan 1, 1991·Free Radical Biology & Medicine·B C WhiteL I Grossman
Mar 8, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·V ParisiB Falsini
Jan 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G BenziA M Giuffrida
Jul 1, 1986·Journal of Neurochemistry·S MykitaR Massarelli
Dec 1, 1985·Biochemical Pharmacology·P GallettiV Zappia

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