Effect of Cefiderocol, a Siderophore Cephalosporin, on QT/QTc Interval in Healthy Adult Subjects

Clinical Therapeutics
Carlos SanabriaTsutae Den Nagata

Abstract

Cefiderocol is a novel siderophore cephalosporin with potent activity against gram-negative bacteria, including multidrug-resistant strains. This Phase I study was conducted to assess the tolerability of single-ascending doses of cefiderocol (part 1) and the effect of cefiderocol on cardiac repolarization, assessed using the electrocardiographic corrected QT interval (QTcF) and other ECG parameters (part 2), in healthy adult subjects. Part 1 was a randomized, double-blind, placebo-controlled, single-ascending dose study in healthy adult male and female subjects. Part 2 was a 4-period crossover study in which subjects received a single 2-g dose of cefiderocol (therapeutic dose), a single 4-g dose of cefiderocol (supratherapeutic dose), or saline (placebo), each infused over 3 hours, and a single oral 400-mg dose of moxifloxacin. In each treatment period, continuous cardiac monitoring was used to assess the effects of cefiderocol on ECG parameters. The QT interval corrected using the Fridericia formula (QTcF) was the primary ECG parameter; the time-matched placebo- and baseline-adjusted (dd)-QTcF interval was the primary end point. The plasma pharmacokinetic properties of cefiderocol were calculated on the basis of concentration-...Continue Reading

Citations

Feb 20, 2020·Infectious Diseases and Therapy·Janet Y WuJason M Pogue
Jun 12, 2020·The Annals of Pharmacotherapy·Rania M El-Lababidi, John George Rizk
Nov 15, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Takayuki KatsubeToshihiro Wajima
Oct 18, 2020·Pharmacotherapy·Jacinda C Abdul-MutakabbirMichael J Rybak
Jan 7, 2021·Infection and Drug Resistance·Daniele Roberto GiacobbeUNKNOWN ISGRI-SITA (Italian Study Group on Resistant Infections of the Italian Society of Anti-infective Therapy)

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