Effect of celiprolol therapy on arterial dilatation in experimental hypertension

British Journal of Pharmacology
J P TolvanenI Pörsti

Abstract

1. It has recently been suggested that therapy with beta-adrenoceptor blockers reduces peripheral arterial resistance via enhanced vascular dilatation. Therefore, we studied the effects of celiprolol, which is a specific beta 1-antagonist that has a weak beta 2-agonist action, on arterial tone in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. 2. Two doses of celiprolol (5 and 50 mg kg-1 day-1) were administered to the SHR, while the WKY rats received only the higher dose of the drug. During the 12-week treatment period the higher dose attenuated the increase in blood pressure by approximately 20 mmHg in SHR, whereas the lower dose was without significant antihypertensive effect. Celiprolol therapy did not affect blood pressure in the normotensive WKY rats. 3. Responses of mesenteric arterial rings in vitro were examined at the end of the study. Interestingly, endothelium-mediated relaxations of noradrenaline (NA)-precontracted rings to acetylcholine (ACh) in the absence and presence of the cyclo-oxygenase inhibitor, diclofenac, were equally enhanced in both celiprolol-treated SHR groups. The nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) practically abolished the relaxations to ACh...Continue Reading

References

May 21, 1979·European Journal of Clinical Pharmacology·T L SvendsenJ Trap-Jensen
Sep 1, 1979·Journal of Cardiovascular Pharmacology·P Lund-Johansen
Jan 1, 1986·Journal of Cardiovascular Pharmacology·A J Man in 't VeldM A Schalekamp
Mar 1, 1988·British Journal of Pharmacology·M Feletou, P M Vanhoutte
Apr 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·S F SteinbergJ P Bilezikian
Jan 1, 1993·Journal of Cardiovascular Pharmacology·M Nakashima, P M Vanhoutte
Apr 1, 1993·British Journal of Pharmacology·P ArvolaI Pörsti
Jul 1, 1995·British Journal of Pharmacology·M KähönenI Pörsti

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Citations

Dec 4, 2003·Pharmacology & Therapeutics·Noboru Toda
Feb 1, 2008·Brain Research·Adriana Cristina Licursi de AlcântaraValéria Paula Sassoli Fazan
Mar 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Xuehai ChenHisayoshi Fujiwara
Feb 10, 1998·Journal of Cardiovascular Pharmacology·K MalminiemiR Huupponen
Mar 27, 2003·Journal of Cardiovascular Pharmacology·Hiroshi AsanumaMasafumi Kitakaze

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