Effect of cell-free layer variation on arteriolar wall shear stress.

Annals of Biomedical Engineering
Bumseok NamgungSangho Kim

Abstract

Relationship between a cell-free layer and wall shear stress (WSS) in small arterioles has been of interest in microcirculatory research. However, influence of temporal variation in the cell-free layer width on the WSS in vivo has not been fully elucidated. In this study, we tested the hypothesis that the layer variation would increase the WSS, and this effect would be enhanced by red blood cell aggregation. The cell-free layer width in arterioles (29.5-67.1 μm ID) in rat cremaster muscles were obtained with a high-speed video camera, and the layer width data were introduced into WSS estimation. Dextran 500 was administrated to elevate the aggregation level of red blood cells to those seen in normal human blood. The variation of the layer was quantified by the variability (coefficient of variation), and its effect on WSS was studied under normal and reduced flow conditions. We found that the dextran-induced red blood cell aggregation significantly elevated the variability (p<0.01) at low pseudoshear rates of 9.2±0.6 s(-1). The WSS estimated without taking account of the variability showed underestimation of its value than that of with consideration of the variability under all flow conditions, and this effect became more pronou...Continue Reading

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Citations

Dec 2, 2010·Annals of Biomedical Engineering·Peng Kai OngSangho Kim
Feb 1, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M WiewioraK Sosada
Oct 23, 2014·Clinical Hemorheology and Microcirculation·Bumseok NamgungSangho Kim
Jan 31, 2013·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Peng Kai Ong, Sangho Kim
Apr 28, 2011·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·C Makena HightowerMarcos Intaglietta
May 18, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Peng Kai OngSangho Kim
Dec 14, 2011·Microvascular Research·Peng Kai OngSangho Kim
Mar 29, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Baraa K Al-KhazrajiDaniel Goldman
Jul 23, 2016·Clinical Hemorheology and Microcirculation·Meongkeun JuSangho Kim
May 29, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Yan Cheng NgSangho Kim
Mar 7, 2019·Biomechanics and Modeling in Mechanobiology·Brenna HoganAbdul I Barakat
Dec 8, 2014·Biomechanics and Modeling in Mechanobiology·Othmane Oulaid, Junfeng Zhang
Nov 19, 2015·Frontiers in Computational Neuroscience·Sang-Woo ParkDaniel M Tartakovsky
Dec 12, 2018·Clinical Hemorheology and Microcirculation·Jerzy PiecuchMaciej Wiewiora
Feb 6, 2017·Journal of the Royal Society, Interface·Woorak ChoiSang Joon Lee
Feb 15, 2018·Frontiers in Physiology·Gregory BarshteinSaul Yedgar

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