PMID: 11255178Mar 20, 2001Paper

Effect of cellulose acetate materials on the oxidative burst of human neutrophils

Journal of Biomedical Materials Research
M A MooreM J Kowolik


Following adverse clinical events involving seven patients undergoing renal dialysis using 12-year-old cellulose acetate hemodialyzers, this in vitro study was proposed in an effort to characterize the inflammatory response to the constituent cellulose acetate (CA) fiber materials. Chemiluminescence (CL) and apoptosis assays were used to determine whether human neutrophils were activated by CA fiber materials and/or are sensitive to degradation/alteration of these fibers over time. Furthermore, the study examined in vitro assays with human neutrophils using a CA film, the solvents used in the film preparation and CA resin. The film could be cut to identical sized pieces in an effort to compare hemodialysis material effects in standardized amounts. For the CL assays, 60-min exposure was followed by secondary stimulation with n-formyl-met-leu-phe (fMLP) or phorbol-12-myristate-13-acetate (PMA). Short-term exposure (60-min postintroduction to CA materials) increased the inflammatory response as measured by the respiratory burst of neutrophils (p < or =.05), with CA fiber exposure significantly compared with cells alone. There was a trend toward an increased response with exposure to older fibers with secondary PMA stimulation. Apo...Continue Reading


Jan 1, 1991·Advances in Experimental Medicine and Biology·M Markert, J P Wauters
Jan 1, 1988·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T KuwaharaJ P Wauters
Jan 1, 1988·Contributions to Nephrology·M MarkertJ P Wauters
Jan 1, 1986·American Journal of Nephrology·A K Cheung, L W Henderson
Feb 20, 1967·JAMA : the Journal of the American Medical Association·G E MooreH A Franklin
Jan 1, 1983·Journal of Clinical Apheresis·L GlasserT H Price
Mar 1, 1980·Transfusion·J McCullough
Jan 1, 1995·Medical Hypotheses·D L LefkowitzN Moguilevsky
Nov 1, 1994·Clinical and Experimental Immunology·A R RosenkranzG J Zlabinger
Dec 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G M HänschE Ritz
Apr 1, 1997·Journal of Leukocyte Biology·J Savill
Aug 1, 1997·Journal of Leukocyte Biology·J A Hamilton
Jan 1, 1997·British Medical Bulletin·C Haslett
Mar 21, 1998·Kidney International·B TaborK Schindhelm
Aug 15, 1998·Annals of the New York Academy of Sciences·M A MooreM J Kowolik
Mar 24, 1999·Journal of Leukocyte Biology·Helen Lundqvist-Gustafsson, T Bengtsson
May 3, 2000·JAMA : the Journal of the American Medical Association·J C HutterW R Jarvis
Sep 14, 2000·Journal of Biomedical Materials Research·A D LucasR R Wallis
Sep 29, 2001·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·J C HutterL W Schroeder


May 13, 2006·Seminars in Dialysis·Zbylut J Twardowski
Feb 6, 2004·Journal of Biomedical Materials Research. Part a·Jenny LarssonHelen Lundqvist-Gustafsson
May 16, 2020·International Journal of Molecular Sciences·Vincenzo LosappioGiovanni Stallone
Aug 22, 2014·The Journal of Veterinary Medical Science·Shunsuke ShimamuraJun Yasuda

Related Concepts

Hemocompatible Materials
Sulfite Cellulose
Communicable Diseases
Renal Dialysis Machine
Phosphorescent Measurements
Hemocompatibility Testing
Neutrophil Band Cells

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Related Papers

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Stanley Shaldon, Karl Martin Koch
ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Marcello TonelliKailash K Jindal
Occupational and Environmental Medicine
M L Flindt
© 2021 Meta ULC. All rights reserved