PMID: 11255178Mar 20, 2001Paper

Effect of cellulose acetate materials on the oxidative burst of human neutrophils

Journal of Biomedical Materials Research
M A MooreM J Kowolik

Abstract

Following adverse clinical events involving seven patients undergoing renal dialysis using 12-year-old cellulose acetate hemodialyzers, this in vitro study was proposed in an effort to characterize the inflammatory response to the constituent cellulose acetate (CA) fiber materials. Chemiluminescence (CL) and apoptosis assays were used to determine whether human neutrophils were activated by CA fiber materials and/or are sensitive to degradation/alteration of these fibers over time. Furthermore, the study examined in vitro assays with human neutrophils using a CA film, the solvents used in the film preparation and CA resin. The film could be cut to identical sized pieces in an effort to compare hemodialysis material effects in standardized amounts. For the CL assays, 60-min exposure was followed by secondary stimulation with n-formyl-met-leu-phe (fMLP) or phorbol-12-myristate-13-acetate (PMA). Short-term exposure (60-min postintroduction to CA materials) increased the inflammatory response as measured by the respiratory burst of neutrophils (p < or =.05), with CA fiber exposure significantly compared with cells alone. There was a trend toward an increased response with exposure to older fibers with secondary PMA stimulation. Apo...Continue Reading

References

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Citations

May 13, 2006·Seminars in Dialysis·Zbylut J Twardowski
Feb 6, 2004·Journal of Biomedical Materials Research. Part a·Jenny LarssonHelen Lundqvist-Gustafsson
May 16, 2020·International Journal of Molecular Sciences·Vincenzo LosappioGiovanni Stallone
Aug 22, 2014·The Journal of Veterinary Medical Science·Shunsuke ShimamuraJun Yasuda

Related Concepts

Acetylcellulose
Hemocompatible Materials
Sulfite Cellulose
Hemodialysis
Communicable Diseases
Inflammation
Renal Dialysis Machine
Phosphorescent Measurements
Hemocompatibility Testing
Neutrophil Band Cells

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