Effect of central depressants on the acoustic middle ear reflex in rabbit. A method for quantitative measurements of drug effect on the CNS.

Acta Physiologica Scandinavica
E Borg, A R Moller

Abstract

The respective effects of pentobarbital-sodium, enibumal-sodium, urethane, urethane-chloralose and lidocaine on the function of the acoustic middle ear reflex in the rabbit were studied. The response of the middle ear muscles was measured by recording changes in both ears' acoustic impedance when the reflex was elicited by applying pure tone stimuli (2,000 Hz) to the two ears one at a time. In that way both the crossed and the uncrossed reflexes were studied. All the drugs were found to depress the reflex in such a way that a higher sound intensity was required after administration to achieve the same impedance change as before. The effect of the anesthetics was roughly proportional to their known anesthetic power. Lidocaine produced only a slight depression of the reflex. The crossed reflex showed a greater susceptibility to the general anesthetics than did the uncrossed reflex which suggests a greater complexity of the crossed reflex. Because the method of recording the reflex response does not require any surgery and is equally well applicable in unrestrained rabbits and in humans, it is suggested as a way of testing the effect of drugs on the central nervous system.

References

Jun 1, 1968·Acta Oto-laryngologica·E Borg, A R Moller
Nov 1, 1960·Electroencephalography and Clinical Neurophysiology·A HUGELINN PAILLAS
Mar 1, 1960·Anesthesiology·R L BORGMANJ P LONG
May 1, 1963·Archives of Neurology·S BLOM
Jul 1, 1963·Journal of Neurophysiology·P W CARMEL, A STARR

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Citations

Jun 9, 2006·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Ole N LarsenAxel Michelsen
Mar 1, 1997·Hearing Research·P K PilzH U Schnitzler
Sep 28, 2010·Trends in Amplification·Sudeep MukerjiDaniel J Lee
Jan 28, 2012·The Journal of the Acoustical Society of America·Brian R Earl, Mark E Chertoff
Jan 1, 1977·Scandinavian Audiology·R E Jirsa, T W Norris
Nov 28, 2012·Neurotoxicology and Teratology·Pierre CampoFrédéric Cosnier
Nov 21, 2007·Hearing Research·Joseph L SmithCharles I Woods
Apr 11, 2012·Journal of Magnetic Resonance Imaging : JMRI·Amanda M LauerWilliam A Edelstein
Nov 1, 1990·American Journal of Otolaryngology·R P LuskR V Lenth
Jan 1, 1979·Acta Oto-laryngologica·S A Counter, E Borg
Nov 5, 2016·Neurotoxicology·Ludivine WathierAxel Gansmüller
Mar 3, 2017·The Journal of Laryngology and Otology·H H ArslanF Yavuz
Mar 18, 2017·Journal of the Association for Research in Otolaryngology : JARO·Yingyue XuJonathan H Siegel
Feb 1, 1983·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J W HallG A Berry

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