PMID: 2511035Jan 1, 1989Paper

Effect of centrophenoxine and BCE-001 treatment on lateral diffusion of proteins in the hepatocyte plasma membrane as revealed by fluorescence recovery after photobleaching in rat liver smears

Experimental Gerontology
I Zs-NagyK Kitani

Abstract

The average lateral diffusion coefficient of proteins (D) in the cell membrane of hepatocytes has been measured in liver smears by fluorescence recovery after photobleaching (FRAP), based on the so-called peroxide-induced autofluorescence (PIAF) deriving from the oxidation of riboflavin bound to membrane proteins. It has been previously shown that D displays a significant negative linear age correlation. The in vivo effects of two drugs were tested on this parameter. Young (2.7 months) and old (24-26 months) male rats received centrophenoxine (CPH) or a new drug (BCE-001) by either intraperitoneal (i.p.) injection or per os through a gastric tube for 26 to 42 days. D was measured on a double-blind basis in the hepatocyte plasma membrane of treated and control groups. The CPH and BCE-001 treatments did not affect the value of D in the young rats. However, the latter drug increased their growth rate. An increase of D in old animals was induced by treatment with either drug. When the drug effects in old rats were compared, BCE-001 proved to be more efficient than CPH, and at the same time was able to significantly retard the age-dependent loss of body weight characteristic of these animals at the age of approximately 2 years. Our ...Continue Reading

References

Dec 20, 1979·Biochimica Et Biophysica Acta·R J Cherry
Nov 21, 1978·Journal of Theoretical Biology·I Zs-Nagy
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J SchlessingerE L Elson
Jan 1, 1989·Archives of Gerontology and Geriatrics·S DamjanovichB Somogyi
Apr 22, 1988·Biochimica Et Biophysica Acta·M NokuboM Ohta
Jan 1, 1974·Annual Review of Biophysics and Bioengineering·M Edidin
Oct 1, 1982·Biophysical Journal·J YguerabideE E Yguerabide
Sep 1, 1980·Mechanisms of Ageing and Development·I Nagy, K Nagy

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Citations

Sep 1, 1994·Archives of Gerontology and Geriatrics·K Kitani
Dec 12, 2001·Experimental Gerontology·S DamjanovichR Gáspár
Jun 30, 1994·Annals of the New York Academy of Sciences·K NagyI Zs-Nagy
Mar 1, 1991·Archives of Gerontology and Geriatrics·I Zs -Nagy

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