PMID: 2499285Feb 1, 1989Paper

Effect of cephalexin on the colonization resistance of the large intestine in experimental animals

Antibiotiki i khimioterapii︠a︡ = Antibiotics and chemoterapy [sic]
A V LapchinskaiaS M Navashin

Abstract

It was shown morphologically and microbiologically that cephalexin administered intragastrically in a dose of 2 g/kg induced deep microecological changes in the cecum of Wistar albino rats. Scanning electron microscopy revealed that a single use of cephalexin in the above dose resulted in almost complete elimination of the biofilm from the surface of the cecum mucosa and it inflammation. This was accompanied by an increase in the number of potentially pathogenic bacteria and broadening of the spectrum of the phage variants of coliform bacilli present in the animal feces, as well as by change the periods of coliform bacilli persisting in the large intestine.

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

Related Papers

Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology
A V LapchinskaiaE M Gorskaia
Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology
E M GorskaiaE V Trapezov
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
M YanH Song
© 2022 Meta ULC. All rights reserved