Effect of cephalothin on measurement of creatinine concentration.

Antimicrobial Agents and Chemotherapy
L I RankinF C Luft

Abstract

Cephalothin, an antibiotic implicated as nephrotoxic, falsely elevates the creatinine concentration as determined by the Jaffé reaction in vitro. We studied this effect in vivo and demonstrated variable degrees of interference in determinations of plasma and urinary creatinine concentrations by two automated methods. Clinicians should be aware of this phenomenon in patients receiving cephalothin, both when monitoring renal function and when assessing patient reliability in the collection of timed urine specimens.

References

Jun 1, 1975·Archives of Internal Medicine·P C CarlingW R McCabe
Jun 1, 1975·Archives of Internal Medicine·F CabanillasC Baldizón
Dec 18, 1972·JAMA : the Journal of the American Medical Association·S N BobrowR C Young
Apr 1, 1970·Southern Medical Journal·M J PickeringJ R Cade

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Citations

Nov 1, 1983·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W M BennettI Singer
Apr 1, 1981·Drug Intelligence & Clinical Pharmacy·J C MannionN G Popovich
May 1, 1993·The Annals of Pharmacotherapy·M P DucharmeG Strohs
Dec 1, 1983·Drug Intelligence & Clinical Pharmacy·M LeBelG P Lewis

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