PMID: 41828Oct 1, 1979

Effect of cerebral extracellular fluid acidity on total and regional cerebral blood flow

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
S L BrittonD G Davies

Abstract

Total and regional cerebral blood flow (CBF), and cerebrospinal fluid (CSF), and arterial blood acid-base status were measured in 26 chloralose-urethan-anesthetized dogs before and after 30 and 60 min of ventriculocisternal perfusion with artificial CSF equilibrated with 7% CO2 and containing either low (8.7 or 9.1 meq/l), normal (19.6 meq/l), or high (34.7 meq/l) bicarbonate ion concentration ([HCO3-]). An inverse linear relationship was observed between the CSF pH and total CBF. Regional blood flow changes were greater in structures that were closest to the ventricular system. In addition, regional blood flow changes were greater in all tissues studied after 60 min of perfusion than after 30. Perfusion with the control [HCO3-] caused no significant changes in either acid-base status or CBF. We believe that the regional cerebral blood flow changes are the result of changes in the H+ concentration gradient across the cerebral extracellular fluid (ECF) space due to the diffusional exchange of HCO3- between CSF and ECF. It is concluded that cerebral ECF acidity is important in the local regulation of cerebral blood flow.

References

Jan 7, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Marta AleksandrowiczEwa Kozniewska
Apr 1, 1988·NMR in Biomedicine·A R LaptookR L Nunnally
Oct 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D Van NimmenI Leusen
Apr 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A R LaptookA M Porter
Mar 27, 2003·Journal of Neurosurgical Anesthesiology·Rikke Bay-HansenMarianne Juhler
Feb 1, 1994·Acta Anaesthesiologica Scandinavica·A WesterlindB Ekström-Jodal

Related Concepts

Cerebral Blood Flow Imaging
Cerebrospinal Fluid pH
Extracellular Space
Brain
Extracellular Fluid
Urethane
Regional Blood Flow
Total Tissue
Carbonic Acid Ions
Cerebrospinal Fluid

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

The American Journal of Physiology
D R MouwN P Mathias
© 2020 Meta ULC. All rights reserved