PMID: 225643Jan 1, 1979

Effect of certain inhibitors of glycoprotein synthesis on cell fusion induced by vesicular stomatitis virus

Microbiology and Immunology
M Takehara

Abstract

The effect of certain metabolic inhibitors on the fusion of BHK-21 cells induced by vesicular stomatitis virus (VSV) was studied. The polykaryocyte formation in infected cells and virus growth were inhibited by 2-deoxy-D-glucose and D-glucosamine. Host-cell proteins synthesis was suppressed profoundly in both BHK-21-KB and B cells infected with VSV. On the other hand, glycoprotein synthesis was significantly enhanced during the polykaryocyte formation in BHK-21-KB cells, while it was suppressed in BHK-21-B cells which were not sensitive to cell fusion by VSV.

References

Jan 1, 1976·Virology·P J BrennanJ Skelly
Jul 1, 1976·The Journal of General Virology·Y NishiyamaI Nagata
Feb 1, 1977·The Journal of General Virology·F Chany-FournierF Lafay
Apr 1, 1973·Virology·R J CourtneyM Benyesh-Melnick
Jan 1, 1972·Archiv für die gesamte Virusforschung·M Takehara
Jan 1, 1970·Advances in Virus Research·G Poste
Apr 1, 1971·The Journal of General Virology·P ReeveG Poste

Citations

Oct 25, 2012·PloS One·Ygara S MendesAndréa C Oliveira
Sep 24, 2004·Gene Therapy·U BlömerU Martin

Related Concepts

Cell Fusion Procedure
Deoxy Sugars
Deoxyglucose
Xicil
Neoglycoproteins
Cricetus
Kidney
Mannose
Protein Biosynthesis
Vesicular stomatitis Indiana virus

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