Effect of cessation of exposure to toluene diisocyanate (TDI) on bronchial mucosa of subjects with TDI-induced asthma

The American Review of Respiratory Disease
M SaettaL M Fabbri

Abstract

The effect of cessation of exposure to toluene diisocyanate (TDI) was studied in six patients with TDI-induced asthma, proved by a positive inhalation challenge with TDI. Bronchial challenges with TDI and methacholine were performed, and lobar bronchial biopsies were taken at diagnosis and 6 months later, after cessation of exposure. Biopsies from four nonasthmatic control subjects were also examined. At diagnosis, asthmatic subjects had thickened reticular basement membrane (p less than 0.05) and increased numbers of mononuclear cells (p less than 0.05) and eosinophils (p less than 0.05) in the lamina propria when compared with control subjects. Electron microscopy showed degranulation of eosinophils and mast cells in asthmatics. Six months after cessation of exposure, the thickness of reticular basement membrane was significantly reduced compared with that at diagnosis (p less than 0.05), and it decreased to values similar to those of control biopsies. Inflammatory cell numbers in bronchial mucosa of asthmatic subjects did not change significantly 6 months after removal from exposure, and degranulation of eosinophils and mast cells was still present. At the end of the study, airway hyperresponsiveness to methacholine and/or s...Continue Reading

Citations

May 1, 2002·Environmental Health and Preventive Medicine·Kazuko NakashimaKanehisa Morimoto
Apr 1, 2002·Environmental Health and Preventive Medicine·Kazuko NakashimaKanehisa Morimoto
Apr 4, 1994·European Journal of Pharmacology·P ChitanoC E Mapp
Dec 1, 1992·Current Opinion in Immunology·C J Corrigan
Feb 11, 2000·The Journal of Allergy and Clinical Immunology·A M VignolaJ Bousquet
Aug 1, 1993·Respiratory Medicine·R AalbersW Timens
Jan 5, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·C MappL M Fabbri
Jul 13, 1995·The New England Journal of Medicine·M Chan-Yeung, J L Malo
Dec 23, 1999·Current Opinion in Pulmonary Medicine·D E Banks, S M Tarlo
Oct 2, 1993·BMJ : British Medical Journal·P J Barnes
Aug 20, 2004·Occupational and Environmental Medicine·T SjåheimJ Kongerud
Mar 1, 1993·British Journal of Industrial Medicine·O VandenplasL M Fabbri
Jun 2, 1998·American Journal of Respiratory and Critical Care Medicine·L M FabbriA Ciaccia
Feb 2, 1999·American Journal of Respiratory and Critical Care Medicine·P ChanezJ Bousquet
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·L FindleyP M Suratt
Feb 1, 1993·The American Review of Respiratory Disease·M SaettaL M Fabbri
Jun 1, 1996·American Journal of Respiratory and Critical Care Medicine·L M Fabbri
Apr 30, 2005·American Journal of Respiratory and Critical Care Medicine·Cristina E MappLeonardo M Fabbri
Oct 22, 2011·International Journal of Environmental Research and Public Health·Annette Fisseler-EckhoffJoachim Schirren
Jun 4, 2010·The Clinical Respiratory Journal·Thomas Sandström
May 12, 2015·European Journal of Pharmacology·Glenn Cruse, Peter Bradding
Jul 10, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Nabeel Farooqui, David Peden
May 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P MaestrelliL M Fabbri
Jan 8, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·Anne A L Hsu, Constance Lo
Apr 20, 2002·Current Opinion in Allergy and Clinical Immunology·D E Banks
Aug 1, 1996·Journal of Occupational and Environmental Medicine·L C Grammer, M A Shaughnessy
Jun 6, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A NomuraK Sekizawa
Jan 1, 1994·International Archives of Occupational and Environmental Health·X BaurG Fruhmann
May 13, 2011·The Cochrane Database of Systematic Reviews·Gerda J de GroeneJos H Verbeek
Jul 4, 2012·Allergy, Asthma & Immunology Research·Giorgio CiprandiGian Luigi Marseglia
Apr 5, 2011·Allergy, Asthma & Immunology Research·Hyun Jung JinHae-Sim Park
Sep 29, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y SumiQ Hamid
Oct 24, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P Maestrelli, M Saetta
Oct 9, 2019·The Cochrane Database of Systematic Reviews·Paul K HennebergerStefania Curti
Jan 18, 2013·Current Opinion in Allergy and Clinical Immunology·Yoo Seob ShinHae-Sim Park
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·J BousquetA M Vignola
Jun 6, 2020·The European Respiratory Journal·Evy E BlommeTania Maes
May 2, 2017·American Journal of Respiratory and Critical Care Medicine·John R Balmes
May 12, 2006·Critical Reviews in Toxicology·Josje H E ArtsCees de Heer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.