Effect of CGS 9896 on stress-induced gastric ulcer in rat

Clinical and Experimental Pharmacology & Physiology
R A Najim, K H Karim

Abstract

1. The effects of CGS 9896, a partial benzodiazepine agonist, and chlordiazepoxide, a full benzodiazepine agonist, on stress-induced gastric ulcers as well as blood glucose were compared. 2. Ulceration in the glandular stomach was induced by 2 h restraint at 4 degrees C. 3. CGS 9896 reduced significantly the ulcer parameters but did not affect blood glucose. The effect of CGS 9896 was dose-dependently blocked by the benzodiazepine antagonist flumazepil. 4. Chlordiazepoxide reduced the ulcer parameters but increased blood glucose. 5. Since CGS 9896 lacks sedative effects but reduced ulcer parameters, the anti-ulcer and sedative effects of drugs acting at benzodiazepine receptors are disassociated. 6. Benzodiazepine-induced hyperglycaemia does not play a major role in the anti-ulcer effects.

References

Jan 1, 1989·Clinical and Experimental Pharmacology & Physiology·R A NajimF H al-Jawad
Mar 1, 1985·British Journal of Pharmacology·K P BhargavaM B Gupta
Jan 1, 1985·Clinical and Experimental Pharmacology & Physiology·M B GuptaK P Bhargava
Nov 1, 1981·British Journal of Pharmacology·S E File, J B Pearce

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Citations

Jan 1, 1994·Neuroscience and Biobehavioral Reviews·G B GlavinR Murison
Sep 21, 2001·Fundamental & Clinical Pharmacology·Y M Al-Mulla HummadiI B Farjou

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