Effect of chain flexibility on cell adhesion: Semi-flexible model-based analysis of cell adhesion to hydrogels

Scientific Reports
Jooyoung LeeSeung Ja Oh

Abstract

Hydrogels have been developed and applied to various biomedical applications due to their biocompatibility. However, understanding of modulation between cells to hydrogel interface is still unclear, and parameters to explain the interaction are not sophisticated enough. In this report, we studied the effect of polymer chain flexibility on cell adhesion to various hydrogel constructs of collagen and fibrin gels. Specifically, novel method of semi-flexible model-based analysis confirmed that chain flexibility mediated microstructure of the hydrogels is a critical factor for cell adhesion on their surfaces. The proposed analysis showed possibility of more accurate prediction of biocompatibility of hydrogels, and it should be considered as one of the important criteria for polymer design and selections for enhancing both biocompatibility and biofunctionality.

References

Dec 11, 1995·Physical Review Letters·F C MacKintoshP A Janmey
May 29, 2004·Science·M L GardelD A Weitz
Nov 19, 2005·Science·Dennis E DischerYu-Li Wang
Mar 1, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rebecca G Wells
Apr 26, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Eva FilováEvzen Amler
Feb 7, 2009·Nature Reviews. Molecular Cell Biology·Benjamin GeigerAlexander D Bershadsky
Apr 15, 2010·Tissue Engineering. Part a·Aleksander SkardalGlenn D Prestwich
May 21, 2010·Biophysical Journal·Izabela K PiechockaGijsje H Koenderink
Dec 7, 2010·Acta Biomaterialia·Laura PescosolidoPietro Matricardi
Feb 10, 2011·Tissue Engineering. Part B, Reviews·Clayton T McKeeChristopher J Murphy
Dec 21, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dong-Hwee Kim, Denis Wirtz
Jun 5, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Andrea M Matuska, Peter S McFetridge
Apr 29, 2015·Nature Communications·Jetze VisserJos Malda
Aug 8, 2015·International Journal of Molecular Sciences·Amelia Ahmad Khalili, Mohd Ridzuan Ahmad
Feb 26, 2016·Cell Adhesion & Migration·Stéphanie M C BruekersWilhelm T S Huck
Apr 30, 2016·ACS Applied Materials & Interfaces·Sjoerd van Helvert, Peter Friedl
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Shanshan GuoXian Jun Loh
Apr 1, 2015·Cell Communication & Adhesion·Sharareh JalaliFarzaneh Safshekan
Apr 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sa LiuYingjun Wang
May 14, 2008·Soft Matter·Jason R Stokes, William J Frith

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Citations

Mar 19, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Miryam Criado-GonzalezEva Harth
Aug 9, 2019·Biomedical Engineering Online·Ruomeng ChenDichen Li
Jan 13, 2021·Journal of Tissue Engineering and Regenerative Medicine·Ramesh SubbiahLuiz E Bertassoni
Feb 17, 2021·ACS Biomaterials Science & Engineering·Cheng-Chen YangYung Chang
Feb 4, 2022·Pharmaceutical Development and Technology·Muhammet Davut ArpaNeslihan Üstündağ Okur

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Methods Mentioned

BETA
optical tweezer

Software Mentioned

JPK

Related Concepts

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Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

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