Effect of change in an inhibitory neurotransmitter of the myenteric plexus on the pathogenetic mechanism of irritable bowel syndrome subgroups in rat models

Chinese Journal of Digestive Diseases
Jun Rong XuWu Ming Kong

Abstract

In order to investigate the effect of change in an inhibitory neurotransmitter of the myenteric plexus on irritable bowel syndrome (IBS) subgroups, the amounts of nitric oxide (NO) in constipation-predominant (C-IBS) and diarrhea-predominant (D-IBS) IBS models in rats were studied. The D-IBS model was created in rats by intracolonic instillation of acetic acid and by restraint stress. The D-IBS control group underwent intracolonic instillation with saline instead. The C-IBS model was created in rats by gastric instillation of 0-4 degrees C cool water daily for 14 days. The C-IBS control group underwent gastric instillation with saline instead. A blank control group was also made. Viscerosomatic sensitivity was assessed with electromyographic (EMG). Abdominal contractions induced by distension of a colonically inserted balloon (0-1.6 mL) was recorded in rats by implanting electrodes in the abdominal external oblique muscle. An India ink gastric instillation experiment was used to detect the bowel movement and fecal pellets formation. Histological analysis of colonic tissue was performed. Nicotinamide dinucleotide phosphate (NADPH)-diaphorase staining was used to detect positive NO neurons in the myenteric plexus. When the balloo...Continue Reading

Citations

Aug 1, 2013·World Journal of Gastroenterology : WJG·Qing-Lin TangMing-Qing Zhang
Mar 25, 2014·Journal of Natural Medicines·Yongjian XiongYuan Lin
Mar 29, 2012·Canadian Journal of Physiology and Pharmacology·Dapeng ChenYuan Lin
Aug 28, 2007·Pharmacology & Therapeutics·Anneke RijnierseAletta D Kraneveld
Mar 18, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y-W TjongC-T Che
Jan 30, 2014·Clinical and Experimental Pharmacology & Physiology·Pedram ParagomiAhmad Reza Dehpour
Jan 29, 2014·Fitoterapia·Yong-Jian XiongYuan Lin
Oct 1, 2013·Pharmaceutical Biology·Dapeng ChenYuan Lin
Aug 21, 2013·Saudi Journal of Biological Sciences·Faiza B Abdu
Jul 13, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaofang LuJing Xie
Oct 21, 2016·Indian Journal of Pharmacology·Tijen Kaya TemizGokhan Koyluoglu
Mar 18, 2015·World Journal of Gastroenterology : WJG·Cheng YangLu-Qing Zhao
Mar 16, 2018·Behavioural Pharmacology·Ana E López-PérezRaquel Abalo
Mar 15, 2016·World Journal of Gastroenterology : WJG·Chao LiangBin Xu
Jan 28, 2021·BMC Gastroenterology·Ilnar F ShaidullovGuzel F Sitdikova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.