PMID: 6974104Jun 1, 1981Paper

Effect of changes in intracellular calcium concentration on the response of isolated frog retina photoreceptors

Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova
K A BykovA V Dmitriev

Abstract

The role of Ca++ in photoreception was studied by releasing these ions in rod cytoplasma from mitochondrias under 2,4 DNP/10(-4) M/action or blocking the transmembrane Ca++ transport by LaCl3 application (0.1; 0.5; 4 mM). The late receptor potential of the frog retina in response to the repeating stimuli after adding 2.4-DNP in the strophantine--containing saline decreases more slowly than in the control. After adding La+++ ions rods and cones generate the receptor potentials of the same amplitude in the Ca++-free solution as in the Ca++--containing medium. La+++ seems to block calcium permeability of the photoreceptor membrane. These results are incompatible with Ca++ inward current as supposed for cones by the Hagins hypothesis. Ca++ seems to act inside photoreceptor as a modulator rather than the transmitter.

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