Effect of chemical enhancers and iontophoresis on thiocolchicoside permeation across rabbit and human skin in vitro

Journal of Pharmaceutical Sciences
Mariella ArtusiPatrizia Santi

Abstract

The aim of this work was to study the permeation of thiocolchicoside across the skin in vitro. The effect of the chemical enhancer lauric acid and the physical technique of iontophoresis was investigated. Permeation experiments were performed in vitro using rabbit ear skin as barrier. The effect of lauric acid at different concentrations (2% and 4%) and of the vehicle (water, ethanol, or ethanol/water) was investigated. The primary effect of lauric acid was on the partitioning parameter, whereas the diffusive parameter did not change significantly. When human epidermis was used, the permeation parameters were generally lower, although not significantly different from rabbit ear skin. The data obtained with full-thickness human skin indicate that, despite the hydrophilic nature of thiocolchicoside, the resistance to drug transport is not limited to the stratum corneum, but that the underlying dermal tissue can also contribute. Iontophoresis enhanced the flux of thiocolchicoside compared with the passive control. The mechanism by which iontophoresis enhanced thiocolchicoside transport across the skin was electroosmosis. The permeation of thiocolchicoside across the skin can be enhanced using chemical or physical penetration enhan...Continue Reading

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Citations

Sep 1, 2005·Pharmaceutical Research·Cristina PadulaPatrizia Santi
Mar 8, 2012·Scientia pharmaceutica·Vinod DhoteDinesh K Mishra
Mar 7, 2014·Drug Development and Industrial Pharmacy·Elizabeth OjewoleThirumala Govender
Aug 10, 2007·Cutaneous and Ocular Toxicology·Parham Mirshahpanah, Howard I Maibach
May 25, 2006·Journal of Pharmaceutical Sciences·A Femenía-FontP Santi
Nov 1, 2008·Journal of Pharmaceutical Sciences·Fabio MarraPatrizia Santi
Sep 3, 2013·Journal of Pharmaceutical Sciences·Stephen G CarterJim E Riviere
Jul 25, 2012·International Journal of Pharmaceutics·Fabio MarraPatrizia Santi
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Jan 22, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sara NicoliPatrizia Santi
Jan 2, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Cristina PadulaPatrizia Santi
Apr 18, 2013·British Journal of Clinical Pharmacology·Matthieu RoustitJean-Luc Cracowski
Feb 24, 2005·International Journal of Pharmaceutics·P SebastianiP Santi
Sep 29, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·C OstacoloP Santi
Jul 25, 2006·International Journal of Pharmaceutics·S NicoliP Santi
Jan 18, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sara Nicoli, Patrizia Santi
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May 21, 2008·International Journal of Cosmetic Science·S PedersenP Santi

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