Effect of chemical immobilization of SDF-1α into muscle-derived scaffolds on angiogenesis and muscle progenitor recruitment

Journal of Tissue Engineering and Regenerative Medicine
Sarah RajabiHossein Baharvand

Abstract

The availability of three-dimensional bioactive scaffolds with enhanced angiogenic capacity that have the capability to recruit tissue specific resident progenitors is of great importance for the regeneration of impaired skeletal muscle. Here, we have investigated whether introduction of chemoattractant factors to tissue specific extracellular matrix promotes cellular behaviour in vitro as well as muscle progenitor recruitment and vascularization in vivo. We developed an interconnective macroporous sponge from decellularized skeletal muscle with maintained biochemical traits of the intact muscle. SDF-1α, a potent cell homing factor involved in muscle repair, was physically adsorbed or chemically immobilized in these muscle-derived sponges. The immobilized sponges showed significantly higher SDF-1α conjugation efficiency along with improved metabolism and infiltration of muscle-derived stem cells in vitro, and thus generated uniform cellular constructs. In vivo, femoral muscle implantation in rats revealed a negligible immune response in all scaffold groups. We observed enhanced engraftment, neovascularization, and infiltration of CXCR4(+) cells in the immobilized-SDF-1α sponge compared with nonimmobilized controls. Although Pax...Continue Reading

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Citations

Apr 2, 2019·Critical Reviews in Biotechnology·Drew KuraitisErik J Suuronen
Aug 29, 2019·Frontiers in Pharmacology·Mathie NajbergEmmanuel Garcion
Jan 13, 2021·Biomaterials Science·Jonathan DoroginMarian H Hettiaratchi
Oct 17, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Aleksandra L PredeinaVladimir V Vinogradov
May 28, 2021·Journal of Biomedical Materials Research. Part a·Miranda M Carleton, Michael V Sefton
Aug 12, 2019·ACS Biomaterials Science & Engineering·Zhaozhao DingDavid L Kaplan
Nov 7, 2021·Nature Reviews. Urology·Erica T Y LeungPhilip C N Chiu
Dec 20, 2021·International Endodontic Journal·Hengameh BakhtiarAnil Kishen

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