PMID: 18705308Aug 19, 2008Paper

Effect of chemoradiotherapy for neural invasion in an advanced esophageal cancer

Hepato-gastroenterology
Akira TanakaHitoshi Shiozaki

Abstract

For esophageal cancer, the incidence of lymphatic, local, and hematogenous recurrence is high, and prognosis is poor. This study examined utility of chemoradiotherapy for neural invasion, a risk factor for local recurrence, and a poor prognosis factor. Neural invasion was studied histochemically in 183 patients with resected advanced esophageal squamous cell carcinoma, of T2 or greater depth of wall invasion. Neural invasion positivity occurred in 78 of 183 (46.2%) patients, 11 of 21 (52.4%) of the preoperative radiotherapy alone group, and 5 of 22 (22.7%) in the preoperative chemoradiotherapy group (p<0.05). The local recurrence rate overall was 15.0% in the preoperative radiotherapy alone group compared to 5.9% in the chemoradiotherapy group. Chemoradiotherapy is effective for neural invasion in comparison with radiotherapy alone.

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.