PMID: 7009446Jan 1, 1980Paper

Effect of chemotherapeutic agents on natural and BCG-stimulated macrophage cytotoxicity in mice

International Journal of Immunopharmacology
A MantovaniF Spreafico

Abstract

Spontaneous or Bacillus Calmette Guérin (BCG)-stimulated macrophage cytotoxicity was investigated in the peritoneal cavity of BALB/c x DBA/2 treated with various chemotherapeutic agents. The SV40-transformed mKSA TU5 (TU5) line and the mFS6 sarcoma were used as targets. Cytolytic activity of macrophages from individual mice (4-6 per experimental group) was measured as release of [3H methyl]thymidine from prelabelled target cells. Treatment with azathioprine (a single injection 100-400 mg/kg or 5 daily doses of 10-80 mg/kg s.c.) and dimethyltriazenoimidazole carboxamide (a single injection of 45-180 mg/kg or 5 daily doses of 3-30 mg/kg i.v.) resulted in marked dose-dependent inhibition of spontaneous macrophage cytotoxicity against TU5 tumor cells 2 days later. By 7 days after drug treatment spontaneous cytotoxicity of macrophages had returned to normal levels. In contrast adriamycin (a single dose of 5-10 mg/kg or 5 daily doses of 0.6-2.5 mg/kg i.v.) and cyclophosphamide (a single dose of 50-200 mg/kg or 5 daily doses of 6-25 mg/kg i.v.) did not affect spontaneous cytolytic activity of murine macrophages. BCG-stimulated macrophage cytotoxicity was investigated using mFS6 target cells which were relatively resistant to the spont...Continue Reading

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Citations

Jan 1, 1985·Springer Seminars in Immunopathology·A G Johnson, J Regal
Jan 1, 1985·Springer Seminars in Immunopathology·F SpreaficoA Montovani
Jan 1, 1983·Comparative Immunology, Microbiology and Infectious Diseases·C VoiculescuC Nedelcu
Jan 1, 1983·International Journal of Immunopharmacology·F SpreaficoF Stirpe
Jan 1, 1988·International Journal of Immunopharmacology·W LuiniF Spreafico
Feb 1, 1992·International Journal of Immunopharmacology·F RigantiA Vecchi
Jan 1, 1992·International Journal of Immunopharmacology·K A GolemboskiR R Dietert
Jan 1, 1994·International Archives of Occupational and Environmental Health·B G SvenssonL Hagmar
Dec 2, 2005·Expert Opinion on Pharmacotherapy·Gabriel Chong, Michael A Morse
Dec 1, 1995·Environmental Health Perspectives·N I Kerkvliet

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