PMID: 25731324Mar 4, 2015Paper

Effect of chemotherapy on the inoperable or recurrent colorectal cancers in patients with lynch syndrome

Gan to kagaku ryoho. Cancer & chemotherapy
Okihide SuzukiHideyuki Ishida

Abstract

We examined the clinicopathological features of 4 patients with Lynch syndrome (including those with strongly suspected Lynch syndrome) who had undergone chemotherapy as part of the treatment for colon cancer. The study population included 3 men and 1 woman. The median age at diagnosis was 72 years (range, 24-40 years). Two patients relapsed and 2 patients had Stage IV cancer. All the patients had primary right-sided colon cancer. On histopathological examination, well differentiated adenocarcinoma, moderately differentiated adenocarcinoma, and poorly differentiated adenocarcinoma were observed in 1, 2, and 1 patients, respectively. Components of mucinous adenocarcinoma or poorly differentiated adenocarcinoma were observed in all patients. Microsatellite instability (MSI) testing revealed high MSI (MSI-H) in all patients. Immunostaining results indicated loss of expression of the MSH2/MSH6 proteins at the tumor site in all patients. With regard to chemotherapy, a 5-fluorouracil-based regimen was selected as the first-line of therapy. Although 1 patient experienced long-term survival (alive at 48 months after surgery), the other 3 patients died of cancer within 9 months. The median overall survival was 8.5 months. Active assessm...Continue Reading

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